国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
17期
2714-2717
,共4页
刘玲%黄斌明%夏曦%江志贵
劉玲%黃斌明%夏晞%江誌貴
류령%황빈명%하희%강지귀
传染性单核细胞增多综合征%病原学%临床特征%儿童
傳染性單覈細胞增多綜閤徵%病原學%臨床特徵%兒童
전염성단핵세포증다종합정%병원학%림상특정%인동
Infectious mononucleosis syndrome%Etiology%Clinical features%Children
目的 探讨儿童传染性单核细胞增多综合征(传单综合征)的病原学和临床特征,以便针对不同病原进行相应治疗,提高疗效和缩短疗程.方法 对35例EB病毒EBV-VCA-IgM、EBV-VCA-IgA阴性而诊断为传单综合征的患儿采用ELISA方法检测患儿血清肺炎支原体抗体(MP-IgM)、巨细胞病毒抗体(CMV-IgM)、腺病毒抗体(ADV-IgM)、柯萨奇病毒抗体(CBV-IgM)、弓形虫抗体(Tox-IgM)、微小病毒抗体(B19-IgM)、乙肝病毒(HBsAg)等,并与同期住院的25例EBV感染的传染性单核细胞增多症(传单)患儿临床体征进行分析比较.结果 35例传单综合征患者MP-IgM大于1:80阳性12例(34.3％),CMV-IgM阳性5例(14.3％)、ADV-IgM阳性2例(5.7％)、CBV-IgM阳性1例(5.7％)、微小病毒抗体(B19-IgM)阳性1例(5.7％)、乙肝病毒(HBsAg)阳性3例(7.9％),传单综合征组与传统的传单组在淋巴结肿大、心肌酶、白细胞计数和异常淋巴细胞比例改变明显(P＜0.05).结论 MP与CMV是引起传单综合征的最常见病因,及早明确病原并相应采用阿奇霉素、红霉素等大环内酯类药物抗支原体治疗和应用更昔洛韦抗病毒治疗均取得良好疗效.
目的 探討兒童傳染性單覈細胞增多綜閤徵(傳單綜閤徵)的病原學和臨床特徵,以便針對不同病原進行相應治療,提高療效和縮短療程.方法 對35例EB病毒EBV-VCA-IgM、EBV-VCA-IgA陰性而診斷為傳單綜閤徵的患兒採用ELISA方法檢測患兒血清肺炎支原體抗體(MP-IgM)、巨細胞病毒抗體(CMV-IgM)、腺病毒抗體(ADV-IgM)、柯薩奇病毒抗體(CBV-IgM)、弓形蟲抗體(Tox-IgM)、微小病毒抗體(B19-IgM)、乙肝病毒(HBsAg)等,併與同期住院的25例EBV感染的傳染性單覈細胞增多癥(傳單)患兒臨床體徵進行分析比較.結果 35例傳單綜閤徵患者MP-IgM大于1:80暘性12例(34.3％),CMV-IgM暘性5例(14.3％)、ADV-IgM暘性2例(5.7％)、CBV-IgM暘性1例(5.7％)、微小病毒抗體(B19-IgM)暘性1例(5.7％)、乙肝病毒(HBsAg)暘性3例(7.9％),傳單綜閤徵組與傳統的傳單組在淋巴結腫大、心肌酶、白細胞計數和異常淋巴細胞比例改變明顯(P＜0.05).結論 MP與CMV是引起傳單綜閤徵的最常見病因,及早明確病原併相應採用阿奇黴素、紅黴素等大環內酯類藥物抗支原體治療和應用更昔洛韋抗病毒治療均取得良好療效.
목적 탐토인동전염성단핵세포증다종합정(전단종합정)적병원학화림상특정,이편침대불동병원진행상응치료,제고료효화축단료정.방법 대35례EB병독EBV-VCA-IgM、EBV-VCA-IgA음성이진단위전단종합정적환인채용ELISA방법검측환인혈청폐염지원체항체(MP-IgM)、거세포병독항체(CMV-IgM)、선병독항체(ADV-IgM)、가살기병독항체(CBV-IgM)、궁형충항체(Tox-IgM)、미소병독항체(B19-IgM)、을간병독(HBsAg)등,병여동기주원적25례EBV감염적전염성단핵세포증다증(전단)환인림상체정진행분석비교.결과 35례전단종합정환자MP-IgM대우1:80양성12례(34.3％),CMV-IgM양성5례(14.3％)、ADV-IgM양성2례(5.7％)、CBV-IgM양성1례(5.7％)、미소병독항체(B19-IgM)양성1례(5.7％)、을간병독(HBsAg)양성3례(7.9％),전단종합정조여전통적전단조재림파결종대、심기매、백세포계수화이상림파세포비례개변명현(P＜0.05).결론 MP여CMV시인기전단종합정적최상견병인,급조명학병원병상응채용아기매소、홍매소등대배내지류약물항지원체치료화응용경석락위항병독치료균취득량호료효.
Objective To explore etiology and clinical features of children infectious mononucleosis syndrome(IMS)and improve curative effect and shorten course of treatment by corresponding treatment according to different pathogens.Methods 35 cases of EB virus(EBV)-VCA-IgM,EBV-VCA-IgA negative were diagnosed with children infectious mononucleosis syndrome,and used ELISA method to detect their serum antibodies with mycoplasma pneumonia(MP-IgM),cytomegalovirus(CMV-IgM),adenovirus antibody (ADV-IgM),Coxsackie virus antibody(CBV-IgM),Toxoplasma antibody(Tox-IgM),parvovirus antibody (B19-IgM)and hepatitis B virus(HBsAg).Selected 25 cases of children infectious mononucleosis(IM)with EBV infection as control group.Results There were 12 cases of MP-IgM positive(more than 1:80)(34.3％),5cases of CMV-IgM positive(14.3％),2 cases of ADV-IgM positive(5.7％),1 case of CBV-IgM positive(5.7％),1 case of parvovirus antibody(B19-IgM)positive(5.7％),3 cases of hepatitis B virus(HBsAg)positive(7.9％)respectively in IMS group.There were significant differences in lymphadenectasis,myocardial enzymes,white blood cell count and atypical lymph cell count between IMS group and IM group(P ＜ 0.05).Conclusion MP and CMV are the most common etiology of IMS.It is important to diagnose and use azithromycin,erythromycin and other macrolides against mycoplasma and ganciclovir anti-virus as early as possible.
