CAJ | 학술논문

在分批发酵中,研究了Streptococcus zooepidemicus SL-1的生长、葡萄糖消耗及透明质酸的产生特性。基于Monod方程和Luedeking-Piret方程,得到了描述分批发酵过程的动力学模型及模型参数,对数生长期最大比生长速率μmax为0.841 g/（g.h）,产物透明质酸最大比生成速率qp1,max为0.54 g/（g.h）。对实验数据与模型模拟值进行拟合,表明该组模型能很好地拟合发酵过程,并在初始葡萄糖浓度变化较大的范围内表现出很好的适用性。
재분비발효중,연구료Streptococcus zooepidemicus SL-1적생장、포도당소모급투명질산적산생특성。기우Monod방정화Luedeking-Piret방정,득도료묘술분비발효과정적동역학모형급모형삼수,대수생장기최대비생장속솔μmax위0.841 g/（g.h）,산물투명질산최대비생성속솔qp1,max위0.54 g/（g.h）。대실험수거여모형모의치진행의합,표명해조모형능흔호지의합발효과정,병재초시포도당농도변화교대적범위내표현출흔호적괄용성。
The fermentation process of hyaluronic acid by Streptococcus zooepidemicus SL-1 with glucose as substrate was studied in batch system.A kinetic model was put forward based on the Monod and Luedeking-Piret equations of cell growth,product generate and substrate consumption.The maximal specific growth rate μmax was 0.841 g/（g· g） in exponential phase.The maximal specific production rate qp1,max could reach 0.54 g/（g· h）in antibiotic production phase.The calculated results of models were compared satisfactorily with experimental data,the model could provide reasonable description for the fermentation process under various initial sugar conditions.