CAJ | 학술논문

采用硼氢化钠（NaBH4）还原二氟乙酸乙酯（CF2HCOOCH2CH3）合成二氟乙醇（HCF2CH20H）。探讨NaBH4用量、溶剂、反应温度和反应时间等因素对反应的影响。实验结果表明：在投料比n（NaBH4）／n（CF2HCOOCH2CH3）=0．6，乙醇为溶剂，温度0℃反应条件下，二氟乙醇的收率可以达到98．1％。在极性溶剂中，随着反应温度的升高（5℃及以上），NaBI-14的分解加剧，低温对反应有利。
채용붕경화납（NaBH4）환원이불을산을지（CF2HCOOCH2CH3）합성이불을순（HCF2CH20H）。탐토NaBH4용량、용제、반응온도화반응시간등인소대반응적영향。실험결과표명：재투료비n（NaBH4）／n（CF2HCOOCH2CH3）=0．6，을순위용제，온도0℃반응조건하，이불을순적수솔가이체도98．1％。재겁성용제중，수착반응온도적승고（5℃급이상），NaBI-14적분해가극，저온대반응유리。
2,2-Difluoroethanol was obtained by reduction of ethyl difluoroacetate using sodium borohydride. Effects of reaction temperature, solvents, reaction time, sodium borohydride dosage, and so on were investigated. The results showed that n（NaBH4）/n（CF2HCOOCHECH3）=0.6, ethanol as solvent at 0℃, the yield of 2,2-difluoroethanol is 98.1% in the reaction. In polarity solvent, with reaction temperature rising （50C and above）, the decomposition of the sodium borohydride intensifies, low temperature is favorite for the reaction.