CAJ | 학술논문

从新疆某鸭场的病鸭中分离到1株大肠杆菌,＂O＂抗原血清学鉴定为O78,药敏试验结果显示该分离株已产生较高程度的耐药性。对鼠疫菌素受体基因fyuA、铁调节蛋白基因irp2、LEE致病岛转录活化因子ler、紧密粘附素eaeA、Ⅰ型菌毛必须蛋白基因fimC、P型菌毛结构基因papA和血清耐受基因iss进行基因测序分析,结果表明该株细菌存在强毒力基因（high-pathogenicity island,HPI）。动物实验表明,该菌可引起雏鸭发生急性全身败血症;10日龄雏鸭半数致死量为2.0×105CFU/ml,表明该菌具有高致病性。
종신강모압장적병압중분리도1주대장간균,＂O＂항원혈청학감정위O78,약민시험결과현시해분리주이산생교고정도적내약성。대서역균소수체기인fyuA、철조절단백기인irp2、LEE치병도전록활화인자ler、긴밀점부소eaeA、Ⅰ형균모필수단백기인fimC、P형균모결구기인papA화혈청내수기인iss진행기인측서분석,결과표명해주세균존재강독력기인（high-pathogenicity island,HPI）。동물실험표명,해균가인기추압발생급성전신패혈증;10일령추압반수치사량위2.0×105CFU/ml,표명해균구유고치병성。
Xinjiang duck field disease duck isolated from 1 strains of Escherichia coli , serological identification of antigens by 078, Drug sensitive test showed that the isolates have a high degree of resistance. The plague bacterium receptor gene fyuA ,Iron regulatory protein gene irp2 ,LEE pathogenicity island of transcriptional activation of factor ler .The tight adhesion of eaeA .Type I pili must protein gene fimC ,The type P pilus structure gene papa and serum resistance gene ISS gene sequencing analysis ,The results showed that the strains of bacteria exist strong virulence ge （high-pathogenicity island, HPI）o Animal experiments show that, The bacteria can cause the occurrence of acute systemic sepsis in ducklings; 10 day old duck half lethal dose2.0＊105 CFU/ml,Show that the bacteria with high pathogenicity.