CAJ | 학술논문

目的：探讨坤泰胶囊对子宫切除术后妇女卵巢功能及围绝经期症状的影响。方法收集来院就诊142例良性病变切除子宫后应用坤泰胶囊治疗的病例资料，与应用雌激素治疗者做比较。结果2组间E2、FSH、LH水平比较差异有统计学意义（FE2=8.217，PE2=0.000；FFSH=6.727，PFSH=0.000；FLH=5.964，PLH=0.000），其中FSH、LH水平坤泰组均高于激素组；E2水平在治疗3个月后比较差异有统计学意义（t=3.149，P=0.004），坤泰组高于激素组；治疗6个月后水平差异无统计学意义（t=0.892，P=0.611）。不同时间E2、FSH、LH分析表明差异有统计学意义（FE2=7.538，PE2=0.000；FFSH=4.558， PFSH=0.007；FLH=12.148，PLH=0.000），两两比较显示治疗后E2水平升高，FSH、LH水平下降。2组间卵巢体积差异无统计学意义（F=0.018，P=0.895）；不同时间卵巢体积差异亦无统计学意义（F=0.112，P=0.798）。2组均未见明显的卵巢血流及窦卵泡变化；2组在改善围绝经期症状总有效率方面差异无统计学意义，坤泰组较激素组乳房胀痛发生例数少，但差异无统计学意义（P>0.05）。结论坤泰胶囊在治疗子宫切除术后患者围绝经期综合征方面有效，为围绝经期综合症患者增加了一种新的选择。
목적：탐토곤태효낭대자궁절제술후부녀란소공능급위절경기증상적영향。방법수집래원취진142례량성병변절제자궁후응용곤태효낭치료적병례자료，여응용자격소치료자주비교。결과2조간E2、FSH、LH수평비교차이유통계학의의（FE2=8.217，PE2=0.000；FFSH=6.727，PFSH=0.000；FLH=5.964，PLH=0.000），기중FSH、LH수평곤태조균고우격소조；E2수평재치료3개월후비교차이유통계학의의（t=3.149，P=0.004），곤태조고우격소조；치료6개월후수평차이무통계학의의（t=0.892，P=0.611）。불동시간E2、FSH、LH분석표명차이유통계학의의（FE2=7.538，PE2=0.000；FFSH=4.558， PFSH=0.007；FLH=12.148，PLH=0.000），량량비교현시치료후E2수평승고，FSH、LH수평하강。2조간란소체적차이무통계학의의（F=0.018，P=0.895）；불동시간란소체적차이역무통계학의의（F=0.112，P=0.798）。2조균미견명현적란소혈류급두란포변화；2조재개선위절경기증상총유효솔방면차이무통계학의의，곤태조교격소조유방창통발생례수소，단차이무통계학의의（P>0.05）。결론곤태효낭재치료자궁절제술후환자위절경기종합정방면유효，위위절경기종합증환자증가료일충신적선택。
Objective To study the effects of Kuntai Capsule on ovarian function perimenopausal symptoms of women with hysterectomy. Methods 142 cases who suffered from benign diseases with hysterectomy were randomly divided into two groups:Kuntai capsule group and estrogen group. Results There were significant difference between the 2 groups about the levels of E2, FSH and LH (FE2=8.217, PE2=0.000. FFSH=6.727, PFSH=0.000. FLH=5.964, PLH=0.000). While the levels of FSH, LH in Kuntai capsule group were higher than those in estrogen group, the difference were signiifcant. The level of E2 in Kuntai capsule group was higher than that of the estrogen group after 3 months therapy (t=3.149, P=0.004), while there was no significant difference after 6 months therapy (t=0.892, P=0.611). The levels of E2, FSH and LH were different between the 2 groups in different therapy times (FE2=7.538, PE2=0.000. FFSH=4.558, PFSH=0.007. FLH=12.148, PLH=0.000). The level of E2 was increased but FSH and LH were decreased. There was no signiifcant difference of ovarian volume between the 2 groups (F=0.018, P=0.895), and the difference of ovarian volume in different therapy times was not signiifcant (F=0.112, P=0.798). The total effective rate of improving perimenopausal symptoms had no signiifcant difference between the 2 groups. The incidence rate of breast distending pain and colporrhagia of Kuntai capsule group were lower than that of estrogen group but the difference was not significant. Conclusion Kuntai Capsule has obvious effects on the treatment of patients with hysterectomy, and it gives a new choice in treating patients with perimenopausal symptoms.