CAJ | 학술논문

为寻找抗血吸虫病的新候选化合物，通过正交实验，高选择性、高产率地合成了染料木素的磺酸酯衍生物.结果表明：小鼠感染血吸虫病，经过衍生物治疗后，由血吸虫导致的肉芽肿面积有不同程度的降低，其中低剂量组降低到23．2％，与溶剂组比较，差异显著(P＜0．05)，优于原药的27．1％及阳性对照组秋水仙碱的27．0％.说明该化合物对血吸虫导致的肉芽肿有一定抑制作用，该化合物有进一步研究价值.
위심조항혈흡충병적신후선화합물，통과정교실험，고선택성、고산솔지합성료염료목소적광산지연생물.결과표명：소서감염혈흡충병，경과연생물치료후，유혈흡충도치적육아종면적유불동정도적강저，기중저제량조강저도23．2％，여용제조비교，차이현저(P＜0．05)，우우원약적27．1％급양성대조조추수선감적27．0％.설명해화합물대혈흡충도치적육아종유일정억제작용，해화합물유진일보연구개치.
Genistein sulfonic acid ester derivative was synthesized in high yield and high selectivity through the orthog-onal experiment to seek new candidate compounds for schistosomiasis.After the mice that infected with schistosomia-sis were treated by the derivative,the granuloma area in mice that were led by schistosome decreased in different de-grees.Among them,the low dosage group reduced to 2 3 .2%,significant difference compared with the solvent group (P<0.05),)better than the parent drug 27.1%and the positive control group 27%.This compound had a certain in-hibitory effect on granuloma in mice that was caused by schistosoma.The mechanism may be the liver functions of mice should be improved after drug treatment.