新医学
新醫學
신의학
NEW CHINESE MEDICINE
2013年
12期
828-831
,共4页
谢汝莹%林硕%王曼曼%林可意%舒礒%穆攀伟%陈燕铭%曾龙驿
謝汝瑩%林碩%王曼曼%林可意%舒礒%穆攀偉%陳燕銘%曾龍驛
사여형%림석%왕만만%림가의%서의%목반위%진연명%증룡역
新诊断%2型糖尿病%血糖波动%胰岛细胞功能
新診斷%2型糖尿病%血糖波動%胰島細胞功能
신진단%2형당뇨병%혈당파동%이도세포공능
Newly diagnosed%Type 2 diabetes%Glucose fluctuation%Pancreatic beta-cell function
目的：探讨新诊断2型糖尿病患者血糖波动与胰岛细胞功能的关系。方法分析51例新诊断2型糖尿病患者的临床资料，血糖波动采用OGTT 1 h与OGTT 0 h差值（GLU1）、OGTT 2 h与OGTT 0 h差值（GLU2）表示。胰岛细胞功能采用空腹血清胰岛素、空腹血清C肽、稳态模式评估法的胰岛素分泌指数（HOMA-β）及胰岛素抵抗指数（HOMA-IR）表示。分析患者血糖波动情况，即GLU1、GLU2与空腹血清胰岛素、空腹血清C肽、HOMA-β、HOMA-IR的相关性。结果该组患者的GLU1为（7.84±2.31）mmol/L，GLU2为（7.4±2.7）mmol/L，空腹血清胰岛素为（13.8±6.0）mU/L，空腹血清C肽为（0.85±0.26）nmol/L，HOMA-β的对数值为4.10±0.64，HOMA-IR的对数值为1.43±0.54。GLU1、GLU2与空腹血清胰岛素、空腹血清C肽、HOMA-IR的对数无相关性（P均＞0.05），但与HOMA-β的对数值呈负相关（r值分别为-0.344、-0.498，P均＜0.05）。结论新诊断2型糖尿病患者血糖波动可能与胰岛素分泌缺陷密切相关。
目的：探討新診斷2型糖尿病患者血糖波動與胰島細胞功能的關繫。方法分析51例新診斷2型糖尿病患者的臨床資料，血糖波動採用OGTT 1 h與OGTT 0 h差值（GLU1）、OGTT 2 h與OGTT 0 h差值（GLU2）錶示。胰島細胞功能採用空腹血清胰島素、空腹血清C肽、穩態模式評估法的胰島素分泌指數（HOMA-β）及胰島素牴抗指數（HOMA-IR）錶示。分析患者血糖波動情況，即GLU1、GLU2與空腹血清胰島素、空腹血清C肽、HOMA-β、HOMA-IR的相關性。結果該組患者的GLU1為（7.84±2.31）mmol/L，GLU2為（7.4±2.7）mmol/L，空腹血清胰島素為（13.8±6.0）mU/L，空腹血清C肽為（0.85±0.26）nmol/L，HOMA-β的對數值為4.10±0.64，HOMA-IR的對數值為1.43±0.54。GLU1、GLU2與空腹血清胰島素、空腹血清C肽、HOMA-IR的對數無相關性（P均＞0.05），但與HOMA-β的對數值呈負相關（r值分彆為-0.344、-0.498，P均＜0.05）。結論新診斷2型糖尿病患者血糖波動可能與胰島素分泌缺陷密切相關。
목적：탐토신진단2형당뇨병환자혈당파동여이도세포공능적관계。방법분석51례신진단2형당뇨병환자적림상자료，혈당파동채용OGTT 1 h여OGTT 0 h차치（GLU1）、OGTT 2 h여OGTT 0 h차치（GLU2）표시。이도세포공능채용공복혈청이도소、공복혈청C태、은태모식평고법적이도소분비지수（HOMA-β）급이도소저항지수（HOMA-IR）표시。분석환자혈당파동정황，즉GLU1、GLU2여공복혈청이도소、공복혈청C태、HOMA-β、HOMA-IR적상관성。결과해조환자적GLU1위（7.84±2.31）mmol/L，GLU2위（7.4±2.7）mmol/L，공복혈청이도소위（13.8±6.0）mU/L，공복혈청C태위（0.85±0.26）nmol/L，HOMA-β적대수치위4.10±0.64，HOMA-IR적대수치위1.43±0.54。GLU1、GLU2여공복혈청이도소、공복혈청C태、HOMA-IR적대수무상관성（P균＞0.05），단여HOMA-β적대수치정부상관（r치분별위-0.344、-0.498，P균＜0.05）。결론신진단2형당뇨병환자혈당파동가능여이도소분비결함밀절상관。
Objective To investigate the relationship between glucose fluctuation and pancreatic be-ta-cell function in patients with newly diagnosed type 2 diabetes. Methods Clinical data of 51 patients with newly diagnosed type 2 diabetes were analyzed. Glucose fluctuation was expressed by the difference between OGTT 1 h and OGTT 0 h (GLU1 )and the difference between OGTT 2 h and OGTT 0 h (GLU2). The correla-tions between GLU1 ,GLU2 and fasting serum insulin,fasting serum C-peptide,homeostasis model assessment-β(HOMA-β)and homeostasis model assessment-insulin resistance (HOMA-IR)were analyzed. Results The value of GLU1 was (7.84 ±2.31 )mmol/L,GLU2 was (7.4 ±2.7 )mmol/L,fasting serum insulin was (13.8 ±6.0)mU/L,fasting serum C-peptide was (0.85 ±0.26)nmol/L,ln (HOMA-β)was 4.10 ± 0.64,ln (HOMA-IR)was 1.43 ±0.54.There were no correlations between GLU1 ,GLU2 and fasting serum insulin,fasting serum C-peptide,ln (HOMA-IR)(P>0.05 ). There were negative correlations between GLU1 ,GLU2 and ln (HOMA-β)(r=-0.344,-0.498,P<0.05 ). Conclusions Glucose fluctuation is closely related to insulin secretory deficiency in patients with newly diagnosed type 2 diabetes.
