CAJ | 학술논문

目的：探讨雌二醇治疗妇女围绝经期综合征的疗效，并对其进行安全性评估。方法选择2010年1月～2011年1月温州市龙湾区第一人民医院妇科收治的64例围绝经期综合征患者作为观察组，该组患者使用戊酸雌二醇治疗；择同期收治的64例围绝经期综合征患者为对照组，该组患者接受常规治疗。治疗结束后,采用汉密尔顿抑郁量表（Hamilton Depression Scale，HAMD）评分和Kupperman评分标准对2组的症状改善效果进行评价，并检测2组治疗前后相关激素水平，观察治疗后不良反应发生情况。结果临床结果显示2组患者治疗后的HAMD评分和Kupperman评分均要显著好于治疗前（P＜0.05），且观察组的改善程度显著好于对照组（P＜0.05）；治疗后观察组的各项激素指标改善效果显著好于对照组（P＜0.05）；观察组治疗后出现8例不良反应，对照组出现12例不良反应，表现为乳房胀痛、阴道出血和胃肠道不适等，2组差异比较不显著。结论雌二醇治疗围绝经期妇女综合症的效果明显，改善了绝经期症状，不良反应少，提高了围绝经期妇女的生活质量。
목적：탐토자이순치료부녀위절경기종합정적료효，병대기진행안전성평고。방법선택2010년1월～2011년1월온주시룡만구제일인민의원부과수치적64례위절경기종합정환자작위관찰조，해조환자사용무산자이순치료；택동기수치적64례위절경기종합정환자위대조조，해조환자접수상규치료。치료결속후,채용한밀이돈억욱량표（Hamilton Depression Scale，HAMD）평분화Kupperman평분표준대2조적증상개선효과진행평개，병검측2조치료전후상관격소수평，관찰치료후불량반응발생정황。결과림상결과현시2조환자치료후적HAMD평분화Kupperman평분균요현저호우치료전（P＜0.05），차관찰조적개선정도현저호우대조조（P＜0.05）；치료후관찰조적각항격소지표개선효과현저호우대조조（P＜0.05）；관찰조치료후출현8례불량반응，대조조출현12례불량반응，표현위유방창통、음도출혈화위장도불괄등，2조차이비교불현저。결론자이순치료위절경기부녀종합증적효과명현，개선료절경기증상，불량반응소，제고료위절경기부녀적생활질량。
Objective To investigate the clinical efifcacy of estradiol on perimenopausal syndrome,and evaluate its safety. Methods 64 cases with perimenopausal syndrome collected in our hospital from January 2010 to January 2011 were used as observation group, and treated with Estradiol valerate. Another 64 cases during the same period were used as control group, and treated with conventional therapy. After treatment, the symptom improvement of both groups were evaluated by the scoring criteria of HAMD and Kupperman, and the related hormone levels were detected and recorded. Adverse reactions after treatment were also observed. Results Clinical results showed that the HAMD and Kupperman score of both groups in end of treatment were better than before treatment, and the improvement degree in observation group were better than control in. The differences were signiifcant (P<0.05). Test results showed that the improvement of various hormonal indicators in observation group were also better than that in control group, the diffierences were significant (P<0.05). 8 cases of adverse reactions were observed in observation group after treatment, 12 cases in control group. Adverse reactions included breast tenderness, vaginal bleeding and gastrointestinal discomfort. The side effects between both groups had no signiifcant difference. Conclusion The efifcacy of Estradiol on perimenopausal syndrome was obvious, it can improve the menopausal symptoms, with less adverse reactions, and improve the life quality of perimenopausal women.