CAJ | 학술논문

目的：探讨丹参酮IIA磺酸钠注射液对冠心病心衰炎性因子及BNP的影响。方法：从入住心内科的病人中筛选符合冠心病心力衰竭的病人60例，其中心功能III级30例，心功能VI级30例；随机分成两组，常规治疗组和丹参酮IIA组。于治疗前、治疗1个疗程（14d）后测定血浆BNP浓度、CRP水平、IL-6水平。结果：应用丹参酮IIA磺酸钠注射液组的血浆炎性因子IL-6、CRP较对照组明显下降且BNP浓度亦明显下降（P<0.05），具有统计学意义。结论：丹参酮IIA磺酸钠注射液可显著降低冠心病心衰患者的血浆炎性因子IL-6、CRP水平，且降低冠心病心衰患者的血浆BNP浓度，有益于冠心病心衰的治疗。
목적：탐토단삼동IIA광산납주사액대관심병심쇠염성인자급BNP적영향。방법：종입주심내과적병인중사선부합관심병심력쇠갈적병인60례，기중심공능III급30례，심공능VI급30례；수궤분성량조，상규치료조화단삼동IIA조。우치료전、치료1개료정（14d）후측정혈장BNP농도、CRP수평、IL-6수평。결과：응용단삼동IIA광산납주사액조적혈장염성인자IL-6、CRP교대조조명현하강차BNP농도역명현하강（P<0.05），구유통계학의의。결론：단삼동IIA광산납주사액가현저강저관심병심쇠환자적혈장염성인자IL-6、CRP수평，차강저관심병심쇠환자적혈장BNP농도，유익우관심병심쇠적치료。
Objective:To explore influence of Tanshinone IIA sulfonate injection on inflammatory factors of coronary heart disease heart failure and BNP. Methods:Check 60 cardiology patients with coronary heart disease heart failure;with 30 cases of NYHA III, 30 cases of NYHA IV; 60 cases were divided into the conventional treatment group and Tanshinone IIA group. Before treatment and after treatment, a course of treatment (14 days) plasma BNP levels, CRP levels, IL-6 levels. Results:The plasma inflammatory cytokines IL-6, CRP of Tanshinone IIA sulfonate injection group decreased more significantly compared with the control group and BNP concentrations also decreased more significantly (P<0.05), with statistical significance. Conclusion:Tanshinone IIA sulfonate injection can significantly reduce plasma inflammatory cytokines IL-6, CRP levels of coronary heart disease patients with heart failure and reduce plasma BNP concentrations, conducive to coronary heart failure treatment.