中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
4期
633-634
,共2页
阿莫西林/克拉维酸钾%小儿化脓性扁桃体炎%治疗
阿莫西林/剋拉維痠鉀%小兒化膿性扁桃體炎%治療
아막서림/극랍유산갑%소인화농성편도체염%치료
Amoxicillin and clavulanate potassium%Pediatric suppurative tonsillitis%Treatment
目的：探讨阿莫西林/克拉维酸钾治疗小儿化脓性扁桃体炎的临床疗效及安全性。方法：化脓性扁桃体炎患儿263例随机分为对照组130例和观察组133例。对照组给予阿奇霉素10 mg·kg-1·d-1,ivd；观察组给予口服阿莫西林/克拉维酸钾分散片。两组均连续治疗3~9d。观察并比较两组临床疗效、临床症状消失时间及不良反应发生情况。结果：治疗后,对照组总有效率为83.8%,观察组总有效率为90.2%；两组总有效率与细菌清除率比较,差异均无统计学意义(P>0.05)。两组患者热退、脓点消失以及血白细胞恢复正常时间也与观察组相当(P>0.05)。两组均未出现明显药品不良反应。结论：阿莫西林/克拉维酸钾治疗小儿化脓性扁桃体炎疗效与阿奇霉素相当,可有效改善临床症状,无明显不良反应,且更加经济、方便,值得临床推广使用。
目的：探討阿莫西林/剋拉維痠鉀治療小兒化膿性扁桃體炎的臨床療效及安全性。方法：化膿性扁桃體炎患兒263例隨機分為對照組130例和觀察組133例。對照組給予阿奇黴素10 mg·kg-1·d-1,ivd；觀察組給予口服阿莫西林/剋拉維痠鉀分散片。兩組均連續治療3~9d。觀察併比較兩組臨床療效、臨床癥狀消失時間及不良反應髮生情況。結果：治療後,對照組總有效率為83.8%,觀察組總有效率為90.2%；兩組總有效率與細菌清除率比較,差異均無統計學意義(P>0.05)。兩組患者熱退、膿點消失以及血白細胞恢複正常時間也與觀察組相噹(P>0.05)。兩組均未齣現明顯藥品不良反應。結論：阿莫西林/剋拉維痠鉀治療小兒化膿性扁桃體炎療效與阿奇黴素相噹,可有效改善臨床癥狀,無明顯不良反應,且更加經濟、方便,值得臨床推廣使用。
목적：탐토아막서림/극랍유산갑치료소인화농성편도체염적림상료효급안전성。방법：화농성편도체염환인263례수궤분위대조조130례화관찰조133례。대조조급여아기매소10 mg·kg-1·d-1,ivd；관찰조급여구복아막서림/극랍유산갑분산편。량조균련속치료3~9d。관찰병비교량조림상료효、림상증상소실시간급불량반응발생정황。결과：치료후,대조조총유효솔위83.8%,관찰조총유효솔위90.2%；량조총유효솔여세균청제솔비교,차이균무통계학의의(P>0.05)。량조환자열퇴、농점소실이급혈백세포회복정상시간야여관찰조상당(P>0.05)。량조균미출현명현약품불량반응。결론：아막서림/극랍유산갑치료소인화농성편도체염료효여아기매소상당,가유효개선림상증상,무명현불량반응,차경가경제、방편,치득림상추엄사용。
Objective:To analyze the clinical efficacy and safety of amoxicillin and clavulanate potassium in the treatment of chil-dren with suppurative tonsillitis. Methods:Totally 263 children with suppurative tonsillitis from March 2011 to September 2013 in pe-diatrics were randomly divided into two groups, the control group had 130 cases and the treatment group had 133 cases. All the patients were given conventional treatment, meanwhile, the control group was with intravenous infusion of azithromycin, and the treatment group was orally given amoxicillin and clavulanate potassium dispersible tablets. The clinical efficacy, clinical symptom disappearance time and the incidence of adverse reactions of the two groups were observed. Results:After the treatment, the control group were cured with the total effective rate of 83. 8%, and the treatment group were healed with the total effective rate of 90. 2%. The difference wasn't sig-nificant (P>0. 05). Orally used amoxicillin and clavulanate potassium was more economic and convenient, which could reduce the drug-resistance as well. There was no significant difference in the effects on fever, purulent and the white blood cell between the two groups, and no significant adverse reactions showed in both groups. Conclusion:Orally used amoxicillin and clavulanate potassium ex-hibits obvious therapeutic effect on infantile suppurative tonsillitis, which can effectively improve the clinical symptoms without obvious adverse reactions, and it is worthy of clinical use.
