中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
4期
641-643
,共3页
曲美他嗪%丹参川芎嗪注射液%不稳定心绞痛%糖尿病
麯美他嗪%丹參川芎嗪註射液%不穩定心絞痛%糖尿病
곡미타진%단삼천궁진주사액%불은정심교통%당뇨병
Trimetazidine%Salvia ligustrazine injections%Unstable angina pectoris%Diabetes
目的：探讨曲美他嗪联合丹参川芎嗪注射液治疗2型糖尿病并冠心病不稳定心绞痛的疗效。方法：76例2型糖尿病合并不稳定型心绞痛患者随机分为对照组和观察组各38例,对照组在常规治疗基础上给予曲美他嗪片20 mg,po,tid,观察组在对照组基础上加用丹参川芎嗪注射液10 ml,ivd,qd。两组疗程均为2周。观察两组治疗后疗效、症状改善、血脂及血液流变学等指标。结果：观察组总有效率为86.84%,高于对照组(65.79%,P<0.05)；血脂及血液流变学指标改善程度也显著优于对照组(P<0.05)；治疗后观察组心绞痛频率、持续时间及硝酸甘油用量均显著低于对照组(P<0.05)。结论：曲美他嗪联合丹参川芎嗪注射液治疗2型糖尿病并冠心病不稳定心绞痛疗效确切,且不良反应少,患者依从性好,值得推广应用。
目的：探討麯美他嗪聯閤丹參川芎嗪註射液治療2型糖尿病併冠心病不穩定心絞痛的療效。方法：76例2型糖尿病閤併不穩定型心絞痛患者隨機分為對照組和觀察組各38例,對照組在常規治療基礎上給予麯美他嗪片20 mg,po,tid,觀察組在對照組基礎上加用丹參川芎嗪註射液10 ml,ivd,qd。兩組療程均為2週。觀察兩組治療後療效、癥狀改善、血脂及血液流變學等指標。結果：觀察組總有效率為86.84%,高于對照組(65.79%,P<0.05)；血脂及血液流變學指標改善程度也顯著優于對照組(P<0.05)；治療後觀察組心絞痛頻率、持續時間及硝痠甘油用量均顯著低于對照組(P<0.05)。結論：麯美他嗪聯閤丹參川芎嗪註射液治療2型糖尿病併冠心病不穩定心絞痛療效確切,且不良反應少,患者依從性好,值得推廣應用。
목적：탐토곡미타진연합단삼천궁진주사액치료2형당뇨병병관심병불은정심교통적료효。방법：76례2형당뇨병합병불은정형심교통환자수궤분위대조조화관찰조각38례,대조조재상규치료기출상급여곡미타진편20 mg,po,tid,관찰조재대조조기출상가용단삼천궁진주사액10 ml,ivd,qd。량조료정균위2주。관찰량조치료후료효、증상개선、혈지급혈액류변학등지표。결과：관찰조총유효솔위86.84%,고우대조조(65.79%,P<0.05)；혈지급혈액류변학지표개선정도야현저우우대조조(P<0.05)；치료후관찰조심교통빈솔、지속시간급초산감유용량균현저저우대조조(P<0.05)。결론：곡미타진연합단삼천궁진주사액치료2형당뇨병병관심병불은정심교통료효학절,차불량반응소,환자의종성호,치득추엄응용。
Objective:To investigate the clinical efficacy of trimetazidine combined with salvia ligustrazine injections in the treat-ment of unstable angina in coronary heart disease with type 2 diabetes. Methods:Totally 76 patients of unstable angina with type 2 di-abetes were randomly divided into the control group and the observation group with 38 cases in each. The control group received trime-tazidine on the basis of the conventional treatment, 20mg,po,tid, while the patients in the observation group received salvia ligustrazine injections additionally, 10ml, ivd,qd. The treatment course was 2 weeks, and the clinical efficacy, blood fat, blood rheology and the other indices were observed after the treatment. Results:After the treatment, the effective rate of the control group and the observation group was 65. 79% and 86. 84%,respectively with statistically significant difference(P<0. 05), the improvement of blood fat and blood rheology in the observation group was better than that in the control group (P<0. 05), the angina frequency and duration, and nitroglycerin consumption in the observation group was significantly lower than those in the control group(P<0. 05). Conclusion:The combination application containing trimetazidine and salvia ligustrazine shows exact clinical efficacy with promising safety and compli-ance, which is valuable in the clinical application.
