浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
8期
666-667,674
,共3页
脑卒中后抑郁%孤啡肽%单胺类神经递质
腦卒中後抑鬱%孤啡肽%單胺類神經遞質
뇌졸중후억욱%고배태%단알류신경체질
Post- stroke depression%Orphanin FQ%Monoamine neurotransmitters
目的：探讨脑卒中后抑郁（PSD）与孤啡肽（OFQ）及单胺类递质之间的相关性。方法将PSD患者102例作为研究组，同期躯体健康、无抑郁的体检者100例作为对照组，比较两者血OFQ及单胺递质含量。结果研究组汉密尔顿抑郁量表（HAMD）评分显著高于对照组（P＜0.01），研究组血OFQ、去甲肾上腺素（NE）含量均高于对照组，血5-羟色胺（5- HT）含量显著低于对照组（均P＜0.05）。研究组OFQ与卒中危险因素间无明显相关性（均P＞0.05），与5- HT含量呈负相关（r=-0.613，P＜0.05），与NE含量、HAMD评分及神经功能缺损（NIHSS）评分呈正相关（r=0.712、0.871、0.443，均P＜0.05）。结论 OFQ与5- HT、NE含量相关，NIHSS评分越高，OFQ含量越高。OFQ有可能通过影响脑内的单胺类神经递质，从而导致PSD症状的发生、发展。
目的：探討腦卒中後抑鬱（PSD）與孤啡肽（OFQ）及單胺類遞質之間的相關性。方法將PSD患者102例作為研究組，同期軀體健康、無抑鬱的體檢者100例作為對照組，比較兩者血OFQ及單胺遞質含量。結果研究組漢密爾頓抑鬱量錶（HAMD）評分顯著高于對照組（P＜0.01），研究組血OFQ、去甲腎上腺素（NE）含量均高于對照組，血5-羥色胺（5- HT）含量顯著低于對照組（均P＜0.05）。研究組OFQ與卒中危險因素間無明顯相關性（均P＞0.05），與5- HT含量呈負相關（r=-0.613，P＜0.05），與NE含量、HAMD評分及神經功能缺損（NIHSS）評分呈正相關（r=0.712、0.871、0.443，均P＜0.05）。結論 OFQ與5- HT、NE含量相關，NIHSS評分越高，OFQ含量越高。OFQ有可能通過影響腦內的單胺類神經遞質，從而導緻PSD癥狀的髮生、髮展。
목적：탐토뇌졸중후억욱（PSD）여고배태（OFQ）급단알류체질지간적상관성。방법장PSD환자102례작위연구조，동기구체건강、무억욱적체검자100례작위대조조，비교량자혈OFQ급단알체질함량。결과연구조한밀이돈억욱량표（HAMD）평분현저고우대조조（P＜0.01），연구조혈OFQ、거갑신상선소（NE）함량균고우대조조，혈5-간색알（5- HT）함량현저저우대조조（균P＜0.05）。연구조OFQ여졸중위험인소간무명현상관성（균P＞0.05），여5- HT함량정부상관（r=-0.613，P＜0.05），여NE함량、HAMD평분급신경공능결손（NIHSS）평분정정상관（r=0.712、0.871、0.443，균P＜0.05）。결론 OFQ여5- HT、NE함량상관，NIHSS평분월고，OFQ함량월고。OFQ유가능통과영향뇌내적단알류신경체질，종이도치PSD증상적발생、발전。
Objective To explore the relationship between post- stroke depression and plasma concentrations of orphanin FQ and monoamine neurotransmitters(NE). Methods One hundred and two patients with post- stroke depression(study group) and 100 healthy subjects without depression (control group) were included in the study. Hamilton Depression Scale (HAMD) was used to evaluate the depression status. The plasma concentrations of orphanin FQ and monoamine neurotransmitters were mea-sured. Results The scores of HAMD in study group were significantly higher than those in control group (P<0.01);the plasma concentrations of OFQ and monoamine NE were significantly higher than those in control group (P<0.05), the concentrations of 5- serotonin(5- HT) in study group were significantly lower than those in control group (P<0.05). There was no significant relation-ship between OFQ and the risk factors of stroke. The OFQ concentration was positively correlated with NE concentration (r=0.712, P<0.05) and HAMD scores (r=0.871, P<0.05), and negatively correlated with 5- HT levels in study group (r=- 0.613, P<0.05). Conclusion Plasma OFQ levels are correlated with 5- HT and NE levels, as wel as with the severity of neurologic deficit (NIHSS score), which indicates that OFQ may lead to the post- stroke depression by interfering with the monoamine neurotransmitters in the brain.
