CAJ | 학술논문

HBV感染后可产生一种保护性抗体抗-HBs，是病毒清除的典型特征。乙型肝炎表面抗原（HBsAg）和抗-HBs序贯表达，理论上在同一患者不可能同时检出。但是近年来，关于HBsAg和抗-HBs同时阳性的报道屡见不鲜。在临床中，HBsAg和抗-HBs同时阳性的现象多见于慢性乙型肝炎患者，及注射乙型肝炎疫苗或使用大剂量单克隆抗-HBs的患者。对于这种特殊现象的发生机制尚不清楚。总结了国内外相关研究结果，分析表明HBsAg和抗-HBs双阳性可能与HBV S基因变异和抗-HBs结合力下降等有关。
HBV감염후가산생일충보호성항체항-HBs，시병독청제적전형특정。을형간염표면항원（HBsAg）화항-HBs서관표체，이론상재동일환자불가능동시검출。단시근년래，관우HBsAg화항-HBs동시양성적보도루견불선。재림상중，HBsAg화항-HBs동시양성적현상다견우만성을형간염환자，급주사을형간염역묘혹사용대제량단극륭항-HBs적환자。대우저충특수현상적발생궤제상불청초。총결료국내외상관연구결과，분석표명HBsAg화항-HBs쌍양성가능여HBV S기인변이화항-HBs결합력하강등유관。
Hepatitis B surface antibody (HBsAb)is formed in response to hepatitic B virus (HBV)infection,which is a typical character-istic of virus clearance.It is theoretically impossible to detect sequential expression of hepatitis B surface antigen (HBsAg)and HBsAb in the same patient.In recent years,however,cases of coexistence of HBsAg and HBsAb have been frequently reported.Clinically,coexis-tence of HBsAg and HBsAb is commonly seen in patients with chronic hepatitis B and those injected with hepatitis B vaccine or given high-dose monoclonal anti-HBs.The mechanism of this special phenomenon remains unclear.The relevant research findings in China and the rest of the world are summarized.Analysis shows that coexistence of HBsAg and HBsAb may be related to HBV S gene mutation,decreased binding force of HBsAb,etc.