CAJ | 학술논문

近20余年来，有关骨桥蛋白（OPN）的生物特性及作用等研究发展迅速。OPN由多种组织细胞合成与分泌。该蛋白结构上与多种基质蛋白相似，功能上具有细胞因子的特点，它在体内参与多种生理和病理活动，包括炎症、损伤修复、骨骼形成和重建，以及癌症和肝脏疾病等。综述了目前有关骨桥蛋白的生物特性研究，及其在肝炎、肝纤维化、肝脏恶性肿瘤中发挥作用等机制。这些资料不仅揭示了相关疾病条件下，OPN在上述疾病发生、发展中所扮演的关键角色，而且指出了通过检测OPN或阻断OPN 表达可以保护和治疗肝炎、肝纤维化、肝脏恶性肿瘤这一潜在的临床意义。
근20여년래，유관골교단백（OPN）적생물특성급작용등연구발전신속。OPN유다충조직세포합성여분비。해단백결구상여다충기질단백상사，공능상구유세포인자적특점，타재체내삼여다충생리화병리활동，포괄염증、손상수복、골격형성화중건，이급암증화간장질병등。종술료목전유관골교단백적생물특성연구，급기재간염、간섬유화、간장악성종류중발휘작용등궤제。저사자료불부게시료상관질병조건하，OPN재상술질병발생、발전중소분연적관건각색，이차지출료통과검측OPN혹조단OPN 표체가이보호화치료간염、간섬유화、간장악성종류저일잠재적림상의의。
There has been rapid research progress in the biological characteristics and function of osteopontin (OPN)over the last 20 years. OPN,synthesized and secreted by many tissue cells,has a similar structure as many matrix proteins and possesses the functional characteris-tics of cytokines.It is involved in the physiological and pathological processes such as inflammation,wound healing,bone formation,and re-modeling,as well as development of cancer and liver diseases.Recent studies on the biological characteristics of OPN and its role in hepati-tis,liver fibrosis,and liver cancer are reviewed.These studies have shown that abnormal changes in OPN expression occur in many liver dis-eases and may play an important role in the development and progression of these diseases and that detecting or suppressing OPN expression is of clinical significance for preventing and treating hepatitis,liver fibrosis,and liver cancer.