中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
2期
71-73
,共3页
舒芬太尼%瑞芬太尼%麻醉效果
舒芬太尼%瑞芬太尼%痳醉效果
서분태니%서분태니%마취효과
sufentanil%remifentanil%anesthesia effect
目的:比较舒芬太尼与瑞芬太尼静脉麻醉的临床效果,为今后的临床实践提供数据支持。方法选取外科手术的患者91例,随机分为2组,即舒芬太尼组(A组)和瑞芬太尼组(B组)进行临床麻醉。在各不同时间点监测患者的血液动力学指标、儿茶酚胺浓度以及术后苏醒情况,并进行对比观察。结果2组患者在气管插管前(T 1)时,各组收缩压(systolic pressure,SP)、舒张压(diastolic pressure,DP)、心率(heart rate,HR)水平比诱导麻醉前(T 0)均有显著下降(P<0.05),到气管插管后1min(T 2)时,SP、DP、HR水平比T1有显著上升(P<0.05),并显著超过了T0的水平(P<0.05),且A组比B组上升的幅度更大(P<0.05)。肾上腺素和去甲肾上腺素在T2和手术结束后30 min(T 6)时,A组水平均比T0有显著提升(P<0.05)。B组患者自主呼吸恢复时间(5.2±1.9)min,睁眼时间(7.2±2.0)min以及意识清醒时间(14.6±2.3)min均少于A组(t=14.382,14.934,12.601,P<0.01),具有统计学差异。2组均未发生不良反应。结论瑞芬太尼组具有良好的麻醉效果,术后患者苏醒快,自我呼吸早。术中血液动力学指标及儿茶酚胺指标变化较为平稳,有利于机体内环境平衡。
目的:比較舒芬太尼與瑞芬太尼靜脈痳醉的臨床效果,為今後的臨床實踐提供數據支持。方法選取外科手術的患者91例,隨機分為2組,即舒芬太尼組(A組)和瑞芬太尼組(B組)進行臨床痳醉。在各不同時間點鑑測患者的血液動力學指標、兒茶酚胺濃度以及術後囌醒情況,併進行對比觀察。結果2組患者在氣管插管前(T 1)時,各組收縮壓(systolic pressure,SP)、舒張壓(diastolic pressure,DP)、心率(heart rate,HR)水平比誘導痳醉前(T 0)均有顯著下降(P<0.05),到氣管插管後1min(T 2)時,SP、DP、HR水平比T1有顯著上升(P<0.05),併顯著超過瞭T0的水平(P<0.05),且A組比B組上升的幅度更大(P<0.05)。腎上腺素和去甲腎上腺素在T2和手術結束後30 min(T 6)時,A組水平均比T0有顯著提升(P<0.05)。B組患者自主呼吸恢複時間(5.2±1.9)min,睜眼時間(7.2±2.0)min以及意識清醒時間(14.6±2.3)min均少于A組(t=14.382,14.934,12.601,P<0.01),具有統計學差異。2組均未髮生不良反應。結論瑞芬太尼組具有良好的痳醉效果,術後患者囌醒快,自我呼吸早。術中血液動力學指標及兒茶酚胺指標變化較為平穩,有利于機體內環境平衡。
목적:비교서분태니여서분태니정맥마취적림상효과,위금후적림상실천제공수거지지。방법선취외과수술적환자91례,수궤분위2조,즉서분태니조(A조)화서분태니조(B조)진행림상마취。재각불동시간점감측환자적혈액동역학지표、인다분알농도이급술후소성정황,병진행대비관찰。결과2조환자재기관삽관전(T 1)시,각조수축압(systolic pressure,SP)、서장압(diastolic pressure,DP)、심솔(heart rate,HR)수평비유도마취전(T 0)균유현저하강(P<0.05),도기관삽관후1min(T 2)시,SP、DP、HR수평비T1유현저상승(P<0.05),병현저초과료T0적수평(P<0.05),차A조비B조상승적폭도경대(P<0.05)。신상선소화거갑신상선소재T2화수술결속후30 min(T 6)시,A조수평균비T0유현저제승(P<0.05)。B조환자자주호흡회복시간(5.2±1.9)min,정안시간(7.2±2.0)min이급의식청성시간(14.6±2.3)min균소우A조(t=14.382,14.934,12.601,P<0.01),구유통계학차이。2조균미발생불량반응。결론서분태니조구유량호적마취효과,술후환자소성쾌,자아호흡조。술중혈액동역학지표급인다분알지표변화교위평은,유리우궤체내배경평형。
Objective To compare the clinical intravenous anesthesia effect of sufentanil and remifentanil respectively, in order to provide data support for future clinical practice. Methods 91 surgery patients from February 2013 to October 2013 were selected and randomly divided into 2 groups, the one is sufentanil group (group A), and the other is remifentanil group(group B). The change of hemodynamic indexes, catecholamine concentration and woke up time after surgery in two groups were monitored and compared. Results Compared with T 0, levels of SP, DP, HR in two groups were signiifcantly lower (P<0.05), at the moment of T 2, the levels of SP, DP, HR level got signiifcantly higher(P<0.05), even surpass T 0(P<0.05). And the range of the rise in group A was signiifcant than that in group B(P<0.05).Epinephrine and norepinephrine of group A in T 2 and T 6, were higher than T 0 (P<0.05). The spontaneous breathing recovery time was, (5.2±1.9)min, open eyes’time, (7.2±2.0) min, and conscious time was(14.6±2.3)min in group B, which were lower than that of group A(t=14.382, 14.934, 14.382, P<0.01).There were no adverse reactions in both groups. Conclusion Remifentanil has good anesthetic effect, postoperative patients wake up soon, self breathing early. The change of hemodynamic index and catecholamine index are stable and beneifcial to internal environment balance.