国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2013年
11期
1038-1042
,共5页
急性肺损伤%多不饱和脂肪酸%炎症
急性肺損傷%多不飽和脂肪痠%炎癥
급성폐손상%다불포화지방산%염증
Acute lung injury%Polyunsaturated fatty acids%Inflammation
背景 急性肺损伤(acute lung injury,ALI)是目前严重威胁人类健康的疾病之一.有大量研究表明:源自多不饱和脂肪酸(polyunsaturated fatty acids,PUFA)的一些特殊的促炎症消退介质(specialized pro-resolving mediators,SPM)对ALI具有一定的保护作用. 目的 分析总结SPM对ALI的保护作用和机制. 内容 此文描述SPM的分子生物学特征、炎症与ALI的关系,SPM的抗炎和促进炎症消退的保护作用及机制3个方面. 趋向 SPM对ALI具有一定的保护作用,这对于临床上治疗ALI提供了一种新的思路和方法.
揹景 急性肺損傷(acute lung injury,ALI)是目前嚴重威脅人類健康的疾病之一.有大量研究錶明:源自多不飽和脂肪痠(polyunsaturated fatty acids,PUFA)的一些特殊的促炎癥消退介質(specialized pro-resolving mediators,SPM)對ALI具有一定的保護作用. 目的 分析總結SPM對ALI的保護作用和機製. 內容 此文描述SPM的分子生物學特徵、炎癥與ALI的關繫,SPM的抗炎和促進炎癥消退的保護作用及機製3箇方麵. 趨嚮 SPM對ALI具有一定的保護作用,這對于臨床上治療ALI提供瞭一種新的思路和方法.
배경 급성폐손상(acute lung injury,ALI)시목전엄중위협인류건강적질병지일.유대량연구표명:원자다불포화지방산(polyunsaturated fatty acids,PUFA)적일사특수적촉염증소퇴개질(specialized pro-resolving mediators,SPM)대ALI구유일정적보호작용. 목적 분석총결SPM대ALI적보호작용화궤제. 내용 차문묘술SPM적분자생물학특정、염증여ALI적관계,SPM적항염화촉진염증소퇴적보호작용급궤제3개방면. 추향 SPM대ALI구유일정적보호작용,저대우림상상치료ALI제공료일충신적사로화방법.
Background Acute lung injury (ALI) is one of the devastating diseases which threat human health.Series of studies have demonstrated the protective effect of Specialized Pro-resolving Mediators (SPM) derived from polyunsaturated fatty acids (PUFA) on ALI.Objective Analyzing and summarizing the protective effect of SPM on ALI and its mechanism.Content This review exposits the molecular biology characteristics of SPM,the relationship between inflammation and acute lung injury and the protective effect and mechanism of anti-inflammation and pro-inflammation resolution of SPM on ALI.Trend With the protective effect on ALI,SPM provides us a new way on the clinical treatment of ALI.
