CAJ | 학술논문

多孔支架是组织工程应用中的关键环节，类似细胞外基质的作用，支撑细胞的粘附和随后细胞向组织的衍化。虽然目前已采用多种制备技术研发出大量的多孔支架，但是多孔生物材料支架的制备和性能优化，仍然是组织工程支架领域的研究热点。结合实验室工作，综述了多种制备不同类型多孔结构生物材料支架的制备技术，主要包括颗粒和纤维堆积型支架、泡沫浸渍法支架和颗粒制孔支架等的制备技术，并阐述了这些制备技术对多孔结构支架的孔结构、贯通性和力学性能的改善效果。其目的旨在提供满足组织工程需求的多孔生物材料支架。
다공지가시조직공정응용중적관건배절，유사세포외기질적작용，지탱세포적점부화수후세포향조직적연화。수연목전이채용다충제비기술연발출대량적다공지가，단시다공생물재료지가적제비화성능우화，잉연시조직공정지가영역적연구열점。결합실험실공작，종술료다충제비불동류형다공결구생물재료지가적제비기술，주요포괄과립화섬유퇴적형지가、포말침지법지가화과립제공지가등적제비기술，병천술료저사제비기술대다공결구지가적공결구、관통성화역학성능적개선효과。기목적지재제공만족조직공정수구적다공생물재료지가。
The porous scaffold is a key factor in the application of tissue engineering. Porous scaffolds which play the role of extracellular matrix similarly provide space for cell adhesion and the subsequent derivation of cells to organization. At present, although a large number of porous scaffolds have been fabricated by various preparation technologies, prepara- tion technologies and performance optimizations of porous biomaterials scaffolds is still a hot topic in the field of tissue en- gineering. Combined with the work in our laboratory, this paper reviewed a variety of preparation technologies （ including particle accumulation method, fiber accumulation method, foam immersion method, particle leaching method, etc. ） of biomaterials scaffolds with various types of porous structure and illustrated the effect on pore structure, connectivity and mechanical property, etc. The aim is to provide a porous biomaterials scaffold to satisfy the need of tissue engineering.