CAJ | 학술논문

由肿瘤、炎症及各类创伤而导致的骨组织坏死、病变、缺失及骨折是临床多发病症，自体骨移植虽然是临床治疗的“金标准”，但由于供体受限而很难满足需求。通过对天然骨本身的成分、结构特性及矿化过程的模仿，应用先进材料制备技术，特别是纳米技术，对材料的组成、结构进行设计与凋控，获得仿生型骨修复材料或者对传统材料进行仿生功能化修饰，以满足临床对痫损或缺失的骨组织进行有效修复和功能重建具有重要意义。阐述了仿生功能化骨修复材料的相关研究，主要包括类骨钙磷纳米矿物的合成，有机分子摸板对纳米矿物尺寸和形貌的调控，以及仿生多孔结构支架的构建等。
유종류、염증급각류창상이도치적골조직배사、병변、결실급골절시림상다발병증，자체골이식수연시림상치료적“금표준”，단유우공체수한이흔난만족수구。통과대천연골본신적성분、결구특성급광화과정적모방，응용선진재료제비기술，특별시납미기술，대재료적조성、결구진행설계여조공，획득방생형골수복재료혹자대전통재료진행방생공능화수식，이만족림상대간손혹결실적골조직진행유효수복화공능중건구유중요의의。천술료방생공능화골수복재료적상관연구，주요포괄류골개린납미광물적합성，유궤분자모판대납미광물척촌화형모적조공，이급방생다공결구지가적구건등。
Bone dethct and bone fracture are common clinical implications due to bone tumor resection, bone necrosis, osteitis and various traumas. Transplantation of autograft that comes from a healthy site in patient to the defect site is the gold standard treatment but the donor shortage limits its application. Mimicking the compositional and structural characteristics of bone and its biomineralization process, biomimetic functionalized bone repair materials can be produced with advanced materials synthesis and processing techniques, in particular nanotechnology development to a precise modulation. This manuscript focuses on the synthesis of nanoscale calcium and phosphate containing minerals, the control of organic molecular templates on the size and morphology of bone-like minerals, as well as the construction of biomimetic porous scaffold.