CAJ | 학술논문

以4-（4-氯丁酰基）-α,α-二甲基苯乙酸甲酯（5）为原料，与4-氰基哌啶（4）缩合，再与二苯甲酮（2）反应得到了2-[4-[4-[4-（羟基二苯甲基）-1-哌啶基]-1-氧代丁基]苯基]-2，2-二甲基乙酸甲酯（1），总收率约79％。该工艺反应条件温和，副反应少，易于操作，是一条适于工业化生产的合成路线。
이4-（4-록정선기）-α,α-이갑기분을산갑지（5）위원료，여4-청기고정（4）축합，재여이분갑동（2）반응득도료2-[4-[4-[4-（간기이분갑기）-1-고정기]-1-양대정기]분기]-2，2-이갑기을산갑지（1），총수솔약79％。해공예반응조건온화，부반응소，역우조작，시일조괄우공업화생산적합성로선。
2-[4-[4-[4-（Hydroxydiphenylmethyl） - 1 -piperidinyl]- 1 -oxobutyl]phenyl]-2,2 -dimethylaeetic acid methyl ester was synthesized from methyl 4-（4-chloro-l-oxobutyl）-α,α-dimethylphenyl acetate with piperidine- 4-carbonitrile to give methyl 2-（4-（4-（4-cyanopiperidin-l-yl）butanoyl）phenyl）-2-methylpropanoate,which was reacted with benzophenone and with an overall yield of 79%. This method is a suitable route for industrial manufacture with advantages of mild condition, few side reaction and easy operation.