CAJ | 학술논문

RpoS蛋白是RNA聚合酶的一种因子,能够调控一组特异性基因的表达,因此在细菌中发挥着至关重要的作用。在细菌中,RpoS蛋白的表达受到严格的控制,主要表现在3个水平的调控：转录水平,翻译水平和翻译后水平环境应力作用通过信号传导进入细菌细胞内,引起一系列微环境的改变,进而引起调控子的变化。通过调控子与RpoS蛋白直接和间接的相互作用,达到控制其水平的目的。另外,由于RpoS蛋白在细菌中有特殊作用,因此RpoS蛋白水平的变化会引起众多基因表达水平的改变,从而引起细菌对不同环境应力应答的变化以及细菌的某些特性的改变,为今后细菌病害的防治提供了新的策略。该文综述了近年来对RpoS蛋白的表达调控以及在几种常见菌种中功能的研究进展,由于RpoS蛋白的功能的复杂性,仍有大量的未知功能有待进一步鉴定。
RpoS단백시RNA취합매적일충인자,능구조공일조특이성기인적표체,인차재세균중발휘착지관중요적작용。재세균중,RpoS단백적표체수도엄격적공제,주요표현재3개수평적조공：전록수평,번역수평화번역후수평배경응력작용통과신호전도진입세균세포내,인기일계렬미배경적개변,진이인기조공자적변화。통과조공자여RpoS단백직접화간접적상호작용,체도공제기수평적목적。령외,유우RpoS단백재세균중유특수작용,인차RpoS단백수평적변화회인기음다기인표체수평적개변,종이인기세균대불동배경응력응답적변화이급세균적모사특성적개변,위금후세균병해적방치제공료신적책략。해문종술료근년래대RpoS단백적표체조공이급재궤충상견균충중공능적연구진전,유우RpoS단백적공능적복잡성,잉유대량적미지공능유대진일보감정。
RpoS protein is a σ factor of RNA polymerase that can control the expression of a group-specific gene, thus playing a vital role in bacteria. In bacteria, RpoS expression is under strict control and is mainly regulated at three levels： transcription level, translation level and post-translational level. Environmental stress enters bacterial cells through signal transduction and leads to a series of variations in microenvironment, thereby causing changes of regulator and controlling its levels based on the direct and indirect interaction between regulator and RpoS protein. In addition, RpoS protein has played special roles in bacteria, therefore the changes of RpoS protein levels will lead to variations in expression levels of a large number of genes, thereby causing variations of bacterial response to different environmental stress and changes of certain characteristics of bacteria, which provides a new strategy for the control of bacterial diseases in the future. This paper reviewed the recent progress on the regulation of RpoS protein expression and its function in several common bacteria. Due to the functional complexity of RpoS protein, there are still a lot of unknown functions to be further identified.