CAJ | 학술논문

考察阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质。利用激光粒度分析仪、透射电镜、扫描电镜、高效液相色谱仪等测定载药纳米粒的形态、粒径、包封率和载药量,并考察载药纳米粒的体外释放行为。考察结果,微球呈类圆形,具有明显的核壳;载药的粒子平均粒径大小为107.96 nm;包封率为（61.24±0.68）%;载药量为（15.36±0.65）%;体外释放符合Higuchi模型。结论：阿昔洛韦/赖氨酸壳聚糖纳米粒理化性能具有良好的稳定性,符合实验设计要求。
고찰아석락위/뢰안산각취당납미립적이화성질。이용격광립도분석의、투사전경、소묘전경、고효액상색보의등측정재약납미립적형태、립경、포봉솔화재약량,병고찰재약납미립적체외석방행위。고찰결과,미구정류원형,구유명현적핵각;재약적입자평균립경대소위107.96 nm;포봉솔위（61.24±0.68）%;재약량위（15.36±0.65）%;체외석방부합Higuchi모형。결론：아석락위/뢰안산각취당납미립이화성능구유량호적은정성,부합실험설계요구。
Objective： To investigate physical and chemical properties of nanoparticles. Methods： Using laser particle size analyzer, transmission electron microscope, scanning electron microscope and high performance liquid chromatograph to determin the form, particle size, entrapment efficiency and drug loading of drug-loaded nanoparticles, and investigate its release behavior. Results： The nanoparticles was spherical with obvious nuclear shell, the nanoparticles had average diameter of 107.96nm, entrapment efficiency of （61.2 ± 0.68）%, drug loading capacity of （15.36 ±0.65）%, and the in virto release effect was true of Higuchi equation.Conclusion： The particle stability of acyclovir lysine-chitosan nanoparticles was tranquilization.