CAJ | 학술논문

[目的]研究乙酰辅酶A羧化酶抑制剂对肥胖小鼠肥胖程度的影响。[方法]建立肥胖动物模型，然后随机分组，试验组以乙酰辅酶A羧化酶抑制剂按照50mg／（kg·bw·d）的剂量灌胃，对照组小鼠以去离子水灌胃。给药过程中，记录小鼠采食量和饮水量的变化情况。给药3周后，测定体重和体长。进行李氏指数的计算；称量脂肪，计算性器官周围脂肪占小鼠体重的比重；测定血清中胆固醇和甘油三酯的相对含量。[结果]乙酰辅酶A羧化酶抑制剂能抑制小鼠体重的增加，可减少肥胖小鼠的肥胖程度；能降低肥胖小鼠血清中的甘油三酯和胆固醇含量。[结论]乙酰辅酶A羧化酶抑制剂对肥胖小鼠有减肥作用，对小鼠的正常饮食没有明显影响。
[목적]연구을선보매A최화매억제제대비반소서비반정도적영향。[방법]건립비반동물모형，연후수궤분조，시험조이을선보매A최화매억제제안조50mg／（kg·bw·d）적제량관위，대조조소서이거리자수관위。급약과정중，기록소서채식량화음수량적변화정황。급약3주후，측정체중화체장。진행리씨지수적계산；칭량지방，계산성기관주위지방점소서체중적비중；측정혈청중담고순화감유삼지적상대함량。[결과]을선보매A최화매억제제능억제소서체중적증가，가감소비반소서적비반정도；능강저비반소서혈청중적감유삼지화담고순함량。[결론]을선보매A최화매억제제대비반소서유감비작용，대소서적정상음식몰유명현영향。
[ Objective ] The research aimed to investigate the effect of the Acetyl-CoA carboxylase inhibitor on the obesity degree of obesity mice. [Method] The obesity animal model was established and mice were randomly divided. Mice in test group was fed with Acetyl-CoA carboxylase inhibitor with the dose of 50 mg/（kg, bw-d）by intragastric administration and mice in control group was treated with deionized water by intragastric administration. The changes of the feed intake and drinking amount of mice in the administration process were recorded. Mice were anatomize after administration three weeks.The body weight and body length were determined, and Lee＇s index was calculated. The fat was weighed and the proportion of the fat around the sexual organs in the body weight of mice was calculated. The relative contention of cholesterol and triglyceride in the serum was measured. [ Result ] Acetyl-CoA carboxylase inhibitor could inhibit the weight increase of mice, reduce the obese degree of obesity mice and decrease the contents of triglyceride and cholesterol in the serum of obesity mice. [ Conclusion ] Acetyl-CoA carboxylase inhibitor had the slimming action on obesity mice, but it had no obvious effect on the normal diet of obesity mice.