国际口腔医学杂志
國際口腔醫學雜誌
국제구강의학잡지
JOURNAL OF INTERNATIONAL STOMATOLOGY
2013年
6期
795-798
,共4页
杨彬(综述)%张志光(审校)
楊彬(綜述)%張誌光(審校)
양빈(종술)%장지광(심교)
SH3PXD2b基因%基因突变%颅颌面畸形%咽鼓管功能障碍%中耳炎
SH3PXD2b基因%基因突變%顱頜麵畸形%嚥鼓管功能障礙%中耳炎
SH3PXD2b기인%기인돌변%로합면기형%인고관공능장애%중이염
srchomology 3 and phox homology domain-containing adaptor protein 2b gene%gene mutation%craniofacial dysmorphology%eustachian tube dysfunction%otitis media
先天性颅颌面畸形作为口腔颌面外科的常见病，多由基因突变引起。先天性颅颌面畸形在影响患者颅颌面形态和功能的同时，多伴随有咽鼓管功能障碍和中耳炎的发生，引起听觉障碍。SH3PXD2b作为新发现的伪足受体蛋白基因，对细胞表面伪足形成、细胞外基质改建与重塑、颅颌面器官的发生有重要的意义。本文就SH3PXD2b基因、SH3PXD2b基因突变、颅颌面畸形与咽鼓管功能障碍和中耳炎等研究进展作一综述。
先天性顱頜麵畸形作為口腔頜麵外科的常見病，多由基因突變引起。先天性顱頜麵畸形在影響患者顱頜麵形態和功能的同時，多伴隨有嚥鼓管功能障礙和中耳炎的髮生，引起聽覺障礙。SH3PXD2b作為新髮現的偽足受體蛋白基因，對細胞錶麵偽足形成、細胞外基質改建與重塑、顱頜麵器官的髮生有重要的意義。本文就SH3PXD2b基因、SH3PXD2b基因突變、顱頜麵畸形與嚥鼓管功能障礙和中耳炎等研究進展作一綜述。
선천성로합면기형작위구강합면외과적상견병，다유기인돌변인기。선천성로합면기형재영향환자로합면형태화공능적동시，다반수유인고관공능장애화중이염적발생，인기은각장애。SH3PXD2b작위신발현적위족수체단백기인，대세포표면위족형성、세포외기질개건여중소、로합면기관적발생유중요적의의。본문취SH3PXD2b기인、SH3PXD2b기인돌변、로합면기형여인고관공능장애화중이염등연구진전작일종술。
Congenital craniofacial dysmorphology is a common disease in oral and maxillofacial surgery that is mainly caused by gene mutation. This disease affects the morphology and function of craniofacial organs. It usually is accompanied by eustachian tube dysfunction and otitis media, which cause hearing impairment. The SH3PXD2b gene is a newly discovered podosome adaptor protein that significantly affects podosome formation, extracellular matrix remodeling, and craniofacial organ development. This article reviews the SH3PXD2b gene, SH3PXD2b gene mutation, and its relationship with craniofacial dysmorphology and otitis media.
