CAJ | 학술논문

克鲁宗综合征是一种颅缝早闭所致的常染色体显性遗传性疾病，表现为尖头畸形，面孔异常，如面中部凹陷和眼球突出等。针对此疾病的治疗方法有手术治疗、物理治疗和基因治疗等，其中以手术治疗为主要手段并针对各种不同的并发症治疗。手术治疗只能作为克鲁宗综合征治疗的一种补救措施，未来能否在胚胎发生期通过基因技术检测克鲁宗综合征，通过药物预防和阻断克鲁宗综合征的发生是临床研究的重点。本文就克鲁宗综合征治疗的手术时机和常用的外科治疗方法等研究进展作一综述。
극로종종합정시일충로봉조폐소치적상염색체현성유전성질병，표현위첨두기형，면공이상，여면중부요함화안구돌출등。침대차질병적치료방법유수술치료、물리치료화기인치료등，기중이수술치료위주요수단병침대각충불동적병발증치료。수술치료지능작위극로종종합정치료적일충보구조시，미래능부재배태발생기통과기인기술검측극로종종합정，통과약물예방화조단극로종종합정적발생시림상연구적중점。본문취극로종종합정치료적수술시궤화상용적외과치료방법등연구진전작일종술。
Crouzon syndrome is an autosomal dominant hereditary disease caused by craniosynostosis that is characterized by hypsicephaly and facial abnormalities such as surface central sag and exophthalmos. Treatment mainly includes surgery, physical therapy, and gene therapy. In particular, surgery is the primary treatment modality and it can be used for a variety of complications. Currently, surgical treatment is merely a remedy for Crouzon syndrome. Future clinical research will determine whether Crouzon syndrome can be diagnosed during embryonic development through gene technology, as well as preventing and blocking the occurrence of Crouzon syndrome through medical treatment. This paper reviews the progress on the surgical timing and treatment methods for Crouzon syndrome.