CAJ | 학술논문

尼尔样-1型分子（NELL-1）是一种在颅缝早闭症早闭区高表达的新型生长因子，对骨软骨细胞系具有高度特异性，具有较强的诱导成骨细胞分化、抑制脂肪细胞成脂化等生物学功能。体内外试验均证实其具有较强的促进新骨再生能力。NELL-1蛋白既可以通过膜内骨化或软骨内骨化促进颅面部和其他部位原位骨组织再生，还可以在小鼠肌袋模型中促进骨髓基质干细胞形成新生骨。与经典的骨组织工程中应用的骨形态发生蛋白等生长因子相比较，单独使用NELL-1蛋白并不能直接诱导肌肉组织中的异位成骨，可见其高度的组织特异性。本文就NELL-1基因、NELL-1基因促进骨组织再生的机制、NELL-1基因促进骨组织再生的应用、NELL-1基因的其他作用等研究进展以及问题和展望作一综述。
니이양-1형분자（NELL-1）시일충재로봉조폐증조폐구고표체적신형생장인자，대골연골세포계구유고도특이성，구유교강적유도성골세포분화、억제지방세포성지화등생물학공능。체내외시험균증실기구유교강적촉진신골재생능력。NELL-1단백기가이통과막내골화혹연골내골화촉진로면부화기타부위원위골조직재생，환가이재소서기대모형중촉진골수기질간세포형성신생골。여경전적골조직공정중응용적골형태발생단백등생장인자상비교，단독사용NELL-1단백병불능직접유도기육조직중적이위성골，가견기고도적조직특이성。본문취NELL-1기인、NELL-1기인촉진골조직재생적궤제、NELL-1기인촉진골조직재생적응용、NELL-1기인적기타작용등연구진전이급문제화전망작일종술。
Nel-like type 1 molecule(NELL-1), a novel growth factor which is found to be overexpressed during premature cranial suture closure in patients with craniosynostosis, is highly specific to the osteochondral lineage and has been recognized to have osteoinductive and anti-adipogenic properties. Moreover NELL-1 has demonstrated robust induction of bone in mutiple in vivo models from rodents to pre-clinical large animals. NELL-1 can promote otrhotopic bone regeneration via either intramembranous or endochondral osssification, both within and outside of the craniofacial complex. Unlike bone morphogenetic protein-2, NELL-1 can not initiate ectopic bone formation in mouse muscle, but can induce bone marrow stromal cells to form bone in a mouse muscle pouch model, exhibiting specifictity the bone morphogenetic proteins lack. NELL-1’s unique role as a novel osteoinductive growth factor makes it an attractive alternative with promise for future clinical applications.