CAJ | 학술논문

目的评价垂体生长激素瘤(GH-secreting pituitary adenoma)患者血清生长激素(GH)水平的改变及其与糖代谢异常的关系. 方法检测GH-secreting pituitary adenoma (GH-secreting pituitary adenoma组)患者BP、血GH、IGF-1及泌乳素,并行75 g OGTT,计算ISI、稳态模型胰岛素抵抗指数(HOMA-IR)、葡萄糖及胰岛素曲线下面积(AUCg,AUCi),将所得结果与垂体无功能瘤(NPA)组及糖代谢正常(NGT组)者进行比较. 结果 GH-secreting pituitary adenoma组血GH、IGF-1、IGF-1％及泌乳素高于其他两组(P＜0.01).GH-secreting pituitary adenoma组IGR及糖尿病患病率高于NPA组及NGT组.GH-secreting pituitary adenoma组FPG、2 hPG高于NGT组,ISI则低于NGT组(P＜0.05或P＜0.01);FIns、AUCg、AUCi及HOMA-IR高于其他两组(P＜0.05或P＜0.01).根据75 g OGTT结果将GH-secreting pituitary adenoma组分为两亚组,高血糖亚组血GH高于血糖正常亚组.相关性分析结果显示,GH-secreting pituitary adenoma组血GH与FPG、2 hPG及AUCg呈正相关;IGF-1％与2hPG及AUCg呈正相关. 结论 GH-secreting pituitary adenoma患者高血糖患病率升高,且其原因与GH高分泌相关.
목적 평개수체생장격소류(GH-secreting pituitary adenoma)환자혈청생장격소(GH)수평적개변급기여당대사이상적관계. 방법 검측GH-secreting pituitary adenoma (GH-secreting pituitary adenoma조)환자BP、혈GH、IGF-1급비유소,병행75 g OGTT,계산ISI、은태모형이도소저항지수(HOMA-IR)、포도당급이도소곡선하면적(AUCg,AUCi),장소득결과여수체무공능류(NPA)조급당대사정상(NGT조)자진행비교. 결과 GH-secreting pituitary adenoma조혈GH、IGF-1、IGF-1％급비유소고우기타량조(P＜0.01).GH-secreting pituitary adenoma조IGR급당뇨병환병솔고우NPA조급NGT조.GH-secreting pituitary adenoma조FPG、2 hPG고우NGT조,ISI칙저우NGT조(P＜0.05혹P＜0.01);FIns、AUCg、AUCi급HOMA-IR고우기타량조(P＜0.05혹P＜0.01).근거75 g OGTT결과장GH-secreting pituitary adenoma조분위량아조,고혈당아조혈GH고우혈당정상아조.상관성분석결과현시,GH-secreting pituitary adenoma조혈GH여FPG、2 hPG급AUCg정정상관;IGF-1％여2hPG급AUCg정정상관. 결론 GH-secreting pituitary adenoma환자고혈당환병솔승고,차기원인여GH고분비상관.