国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2009年
10期
703-706
,共4页
吲哚胺2,3双加氧酶%移植耐受%肿瘤逃逸
吲哚胺2,3雙加氧酶%移植耐受%腫瘤逃逸
신타알2,3쌍가양매%이식내수%종류도일
indoleamine 2,3-dioxygenase%transplantation tolerance%tumor escape
吲哚胺2,3双加氧酶(IDO)是一种能分解色氨酸的细胞内血红素单体蛋白,实验证明通过色氨酸的剥夺和分解产物聚集可以抑制T细胞成熟并促其凋亡.随着对IDO免疫调节机制研究的不断累积,其在器官移植和肿瘤治疗等领域的临床应用前景令人期待.本文就IDO的免疫调节机制及在移植耐受和肿瘤逃逸中的作用做一综述.
吲哚胺2,3雙加氧酶(IDO)是一種能分解色氨痠的細胞內血紅素單體蛋白,實驗證明通過色氨痠的剝奪和分解產物聚集可以抑製T細胞成熟併促其凋亡.隨著對IDO免疫調節機製研究的不斷纍積,其在器官移植和腫瘤治療等領域的臨床應用前景令人期待.本文就IDO的免疫調節機製及在移植耐受和腫瘤逃逸中的作用做一綜述.
신타알2,3쌍가양매(IDO)시일충능분해색안산적세포내혈홍소단체단백,실험증명통과색안산적박탈화분해산물취집가이억제T세포성숙병촉기조망.수착대IDO면역조절궤제연구적불단루적,기재기관이식화종류치료등영역적림상응용전경령인기대.본문취IDO적면역조절궤제급재이식내수화종류도일중적작용주일종술.
Indoleamine 2,3-dioxygenase(IDO)is an intracellular hemeprotein enzyme which catalyses the essential amino acid tryptophan.Accumulating evidences have demonstrated that tryptophan depletion and its toxic metabolites can suppress local allogeneic T cell proliferation and lead to apoptosis.With the study of the mechanism of immune regulation of IDO goes further,it have emerged as a proming enzyme in organ transplantation and tumor treatment.We reviewed in the article the immune regulative mechanism of IDO and its effects in transplantation tolerance and tumor escape.
