CAJ | 학술논문

改进了除草剂氟噻草胺的合成工艺：以氨基硫脲为原料，与三氟乙酸环合生成2-氨基-5-三氟甲基-1，3，4-噻二唑，再经重氮化反应生成2-氯-5-三氟甲基-1，3，4-噻二唑，最后与2-羟基-N-（4-氟苯胺）-N-（1-甲基乙基）乙酰胺反应，经后处理得氟噻草胺。该工艺路线流程短、产品效率高、含量高、三废少且反应条件温和，易于操作和控制，适合工业化生产。文章还对主要因素的影响进行了实验与分析。
개진료제초제불새초알적합성공예：이안기류뇨위원료，여삼불을산배합생성2-안기-5-삼불갑기-1，3，4-새이서，재경중담화반응생성2-록-5-삼불갑기-1，3，4-새이서，최후여2-간기-N-（4-불분알）-N-（1-갑기을기）을선알반응，경후처리득불새초알。해공예로선류정단、산품효솔고、함량고、삼폐소차반응조건온화，역우조작화공제，괄합공업화생산。문장환대주요인소적영향진행료실험여분석。
The paper studied on the flufenacet’s synthesis process, which is greatly improved: aminothiourea is taken as the raw materials, cyclized with trifluoroacetic acid to generate 2-amino-5-trifluoromethyl-1, 3, 4-thiadiazol, then the product 2-chloro-5-trifluoromethyl-1, 3, 4-thiadiazole is got through diazotization, fi-nally reacted with 2-hydroxy-N-(4-fluorophenyl)-N-(isopropyl) acetamide to generate flufenacet after treat-ment. The route is suitable for the industrial production with the characteristics of short process, high efficacy and yields, mild reaction condition, which is conducive to operate and control.