CAJ | 학술논문

目的：探讨阿立哌唑与利培酮治疗儿童青少年首发精神分裂症的临床疗效和安全性。方法将60例儿童青少年首发精神分裂症患者随机分为两组，每组30例，分别口服阿立哌唑与利培酮治疗，观察8周。采用阳性与阴性症状量表评定临床疗效，副反应量表定疗不良反应。结果治疗8周末阿立哌唑组显效率为66．7％、有效率为90．0％，利培酮组分别为70．0％、93．3％，两组比较差异无显著性（ P＞0．05）；阿立哌唑组出现兴奋激越、恶心呕吐不良反应发生率显著高于利培酮组（P＜0．05），肌强直、静坐不能、震颤、体质量增加、月经紊乱不良反应发生率显著低于利培酮组（ P＜0．05或0．01）。结论阿立哌唑与利培酮治疗儿童青少年首发精神分裂症疗效均显著，但阿立哌唑治疗安全性更高，依从性更好。
목적：탐토아립고서여리배동치료인동청소년수발정신분렬증적림상료효화안전성。방법장60례인동청소년수발정신분렬증환자수궤분위량조，매조30례，분별구복아립고서여리배동치료，관찰8주。채용양성여음성증상량표평정림상료효，부반응량표정료불량반응。결과치료8주말아립고서조현효솔위66．7％、유효솔위90．0％，리배동조분별위70．0％、93．3％，량조비교차이무현저성（ P＞0．05）；아립고서조출현흥강격월、악심구토불량반응발생솔현저고우리배동조（P＜0．05），기강직、정좌불능、진전、체질량증가、월경문란불량반응발생솔현저저우리배동조（ P＜0．05혹0．01）。결론아립고서여리배동치료인동청소년수발정신분렬증료효균현저，단아립고서치료안전성경고，의종성경호。
Objective To explore the efficacy and safety of aripiprazole vs .risperidone in the treatment of child and adolescent first-episode schizophrenia .Methods Sixty patients with child and adolescent first-episode schizophrenia were randomly assigned to two groups of 30 ones each ,they respectively took rally aripiprazole and risperidone for 8 weeks .Efficacies were assessed with the Positive and Negative Syndrome Scale (PANSS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 8th week obvious effective and effective rate were respectively 66 .7% and 90 .0% in aripi-prazole and 70 .0% and 93 .3% in risperidone group ,which showed no significant group differences (P>0 .05);incidences of excitation/agitation ,nausea and vomiting were significantly higher (P< 0 .05) and those of myotonia ,akathisia ,tremor ,weight gain and menstrual disorder lower (P< 0 .05 or 0 .01) in aripiprazole than in risperidone group .Conclusion Both aripiprazole and risperidone have an evident effect in the treatment of child and adolescent first-episode schizophrenia ,but the former has higher safety and better compliance .