CAJ | 학술논문

在神经系统与骨代谢关系的研究中，神经肽起着重要作用，尤其是神经肽Y（Neuropeptide Y，NPY）。 NPY可通过结合其特异性Y受体，尤其是Y1受体和Y2受体，来调节成骨细胞和破骨细胞的活性，在骨的生理与病理过程中起重要作用。通过简要介绍NPY及其受体的分布特点与作用，从骨形成、骨吸收及骨愈合方面分析了NPY对骨代谢的调节作用，以期进一步加深NPY对骨代谢调节的认识。
재신경계통여골대사관계적연구중，신경태기착중요작용，우기시신경태Y（Neuropeptide Y，NPY）。 NPY가통과결합기특이성Y수체，우기시Y1수체화Y2수체，래조절성골세포화파골세포적활성，재골적생리여병리과정중기중요작용。통과간요개소NPY급기수체적분포특점여작용，종골형성、골흡수급골유합방면분석료NPY대골대사적조절작용，이기진일보가심NPY대골대사조절적인식。
In the study of the relation between nervous system and bone metabolism, neuropeptides, especially neuropeptide Y (NPY), play an important role.NPY can regulate the activity of osteoblasts and osteoclasts through binding with the specific Y receptor, especially Y1 receptor and Y2 receptor, to play an important role in the physiological and pathological process of bone. This article briefly introduces the distribution and function of NPY and its receptors, and analyzes the regulating effect of NPY on bone metabolism from the aspects of bone resorption, bone formation, and bone healing, in order to deepen the understanding of the regulation of NPY on bone metabolism.