中医药学报
中醫藥學報
중의약학보
ACTA CHINESE MEDICINE AND PHARMACOLOGY
2014年
2期
118-120
,共3页
舒肝解郁胶囊%舍曲林%老年%抑郁症
舒肝解鬱膠囊%捨麯林%老年%抑鬱癥
서간해욱효낭%사곡림%노년%억욱증
Shugan Jieyu capsule%Sertraline%The elderly depression
目的:探讨舒肝解郁胶囊联合舍曲林治疗抑郁症老年患者的临床疗效。方法:选取160例老年抑郁症患者,按双盲原则随机分为观察组和对照组各80例,观察组采用舒肝解郁胶囊联合舍曲林治疗,对照组采用舍曲林治疗,观察并比较两组患者的HAMD的评分变化、临床疗效及不良反应发生率。结果:治疗8周后,两组的HAMD评分均较治疗前明显改善,观察组的改善情况明显优于对照组观察组的总有效率(92.5%)明显高于对照组(68.75%),观察组不良反应发生率(21.25%)与对照组(18.75%)比较无显著性差异( P>0.05)。结论:舒肝解郁胶囊联合舍曲林治疗老年抑郁症患者,临床疗效显著,安全性高,值得临床推广。
目的:探討舒肝解鬱膠囊聯閤捨麯林治療抑鬱癥老年患者的臨床療效。方法:選取160例老年抑鬱癥患者,按雙盲原則隨機分為觀察組和對照組各80例,觀察組採用舒肝解鬱膠囊聯閤捨麯林治療,對照組採用捨麯林治療,觀察併比較兩組患者的HAMD的評分變化、臨床療效及不良反應髮生率。結果:治療8週後,兩組的HAMD評分均較治療前明顯改善,觀察組的改善情況明顯優于對照組觀察組的總有效率(92.5%)明顯高于對照組(68.75%),觀察組不良反應髮生率(21.25%)與對照組(18.75%)比較無顯著性差異( P>0.05)。結論:舒肝解鬱膠囊聯閤捨麯林治療老年抑鬱癥患者,臨床療效顯著,安全性高,值得臨床推廣。
목적:탐토서간해욱효낭연합사곡림치료억욱증노년환자적림상료효。방법:선취160례노년억욱증환자,안쌍맹원칙수궤분위관찰조화대조조각80례,관찰조채용서간해욱효낭연합사곡림치료,대조조채용사곡림치료,관찰병비교량조환자적HAMD적평분변화、림상료효급불량반응발생솔。결과:치료8주후,량조적HAMD평분균교치료전명현개선,관찰조적개선정황명현우우대조조관찰조적총유효솔(92.5%)명현고우대조조(68.75%),관찰조불량반응발생솔(21.25%)여대조조(18.75%)비교무현저성차이( P>0.05)。결론:서간해욱효낭연합사곡림치료노년억욱증환자,림상료효현저,안전성고,치득림상추엄。
Objective:To investigate the curative effect on senile depression treated by Shugan Jieyu capsule combined with sertraline .Methods:Select 160 cases of senile depression patients and they were divided into observation group and control group with 80 cases in each group .According to double-blind principle ,observation group was given the Shugan Jieyu capsule combined with sertraline therapy , and the control group was treated with sertraline .Observe and compare the HAMD score changes , clinical efficacy and adverse reactions in two groups .Results:8 weeks after treatment , HAMD scores of two groups were markedly improved , and the improvement of observation group was obviously better than that in the control group;total effective rate ( 92 .5%) of the observation group was obviously higher than that of control group (68.75%);the incidence of adverse reactions of observation group (21.25%) compared with that of con-trol group (18.75%), and there was no significant difference (P>0.05).Conclusion:The clinical curative effect on senile depression treated by Shugan Jieyu capsule combined with sertraline is distinct , high safety and worth clinical pro-motion.