CAJ | 학술논문

目的：评价急性心肌梗死患者中采取早期开通梗死相关动脉行溶栓治疗对血浆脑钠素(BNP)水平及左心功能的改善效果。方法选择我院92例急性心肌梗死患者，均为首次发病，且发病时间均在12h内，随机分为两组各46例，对照组未开通梗死相关动脉溶栓，观察组早期开通梗死相关动脉溶栓。全部在入院时和发病1周后对血浆BNP进行检测，并在1周后检查超声心动图，分析两组患者的左心重构及左心功能情况，并比较不良事件发生率。结果观察组1周后血浆BNP水平较观察组低(P <0.05)，且观察组左心功能各项指标情况较对照组改善更为明显(P <0.05)。观察组不良事件发生率显著低于对照组(P <0.05)。结论早期开通梗死相关动脉溶栓治疗急性心肌梗死能有效降低血浆BNP浓度，并对左室重构产生一定抑制作用，有效改善左心功能各项指标，从而降低了心脏不良事件的发生率。
목적：평개급성심기경사환자중채취조기개통경사상관동맥행용전치료대혈장뇌납소(BNP)수평급좌심공능적개선효과。방법선택아원92례급성심기경사환자，균위수차발병，차발병시간균재12h내，수궤분위량조각46례，대조조미개통경사상관동맥용전，관찰조조기개통경사상관동맥용전。전부재입원시화발병1주후대혈장BNP진행검측，병재1주후검사초성심동도，분석량조환자적좌심중구급좌심공능정황，병비교불량사건발생솔。결과관찰조1주후혈장BNP수평교관찰조저(P <0.05)，차관찰조좌심공능각항지표정황교대조조개선경위명현(P <0.05)。관찰조불량사건발생솔현저저우대조조(P <0.05)。결론조기개통경사상관동맥용전치료급성심기경사능유효강저혈장BNP농도，병대좌실중구산생일정억제작용，유효개선좌심공능각항지표，종이강저료심장불량사건적발생솔。
Objective To evaluate the effect of early recanalization of the infarct related artery thrombolytic therapy on left ventricular function and BNP level in patients with acute myocardial infarction. Methods 92 patients with acute myocardial infarction were divided into control and observation group randomly, with 46 patients in each group, the onset time of all the patients were within 12h, and all were the first onset. Patients in control group were given conventional treatment, and patients in observation group were given early recanalization of the infarct related artery thrombolytic therapy. Plasma BNP level of all the patients were tested on admission and 1 week after onset, left ventricular remodeling and left ventricular function were recorded and analyzed by echocardiography,And carries on the comparison to the incidence of adverse events. Results Plasma BNP level in observation group were lower than in control group significantly(P <0.05). The left ventricular function situation in observation group was better than in control group significantly(P <0.05). Observation group, incidence of adverse events was significantly lower than the control group(P <0.05). Conclusion Early recanalization of the infarct related artery thrombolytic therapy reduced plasma BNP concentration and has a certain inhibitory action on the left ventricular remodeling, it improves left heart function situation effectively leading to low incidence of adverse cardiac events in patients with acute myocardial infarction.