中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
20期
9166-9169
,共4页
杨敏星%刘剑羽%高宝祥
楊敏星%劉劍羽%高寶祥
양민성%류검우%고보상
前列腺肿瘤%磁共振成像,弥散%表观弥散系数
前列腺腫瘤%磁共振成像,瀰散%錶觀瀰散繫數
전렬선종류%자공진성상,미산%표관미산계수
Prostatic neoplasms%Diffusion megnetic resonance imaging%Apparent diffusion coefficient
目的：探讨3.0 T磁共振弥散加权成像（diffusion-weighted imaging，DWI）对前列腺癌的诊断和鉴别诊断价值。方法应用3.0 T MR成像仪对36例前列腺特异抗原升高疑有前列腺癌的患者进行前列腺MRI高分辨成像及单次激发EPI序列的弥散加权成像，b值分别取0、1000 s/mm2。将前列腺外周带以六分区划分，观察T2WI图及DWI图，并测定各区的表观弥散系数（apparent diffusion coefficient，ADC）值。所有患者均行超声引导下系统穿刺活检证实，依病理结果将其分为前列腺癌区、良性前列腺增生区及慢性炎症区。对所得数据进行统计分析。结果14例前列腺癌、20例良性前列腺增生及2例慢性前列腺炎患者获得可靠 ADC 值。与良性前列腺增生的 ADC 值[（1.72±0.28）×10-3 mm2/s]比较，前列腺癌的ADC 值明显减低[（1.13±0.31）×10-3 mm2/s]，差异具有统计学意义（P＜0.001）。ROC 曲线上临界点取1.31×10-3 mm2/s时，癌和非癌鉴别诊断的敏感性为61.0%，特异性为85.7%。结论3.0 T DWI的ADC值有助于前列腺癌的鉴别诊断。
目的：探討3.0 T磁共振瀰散加權成像（diffusion-weighted imaging，DWI）對前列腺癌的診斷和鑒彆診斷價值。方法應用3.0 T MR成像儀對36例前列腺特異抗原升高疑有前列腺癌的患者進行前列腺MRI高分辨成像及單次激髮EPI序列的瀰散加權成像，b值分彆取0、1000 s/mm2。將前列腺外週帶以六分區劃分，觀察T2WI圖及DWI圖，併測定各區的錶觀瀰散繫數（apparent diffusion coefficient，ADC）值。所有患者均行超聲引導下繫統穿刺活檢證實，依病理結果將其分為前列腺癌區、良性前列腺增生區及慢性炎癥區。對所得數據進行統計分析。結果14例前列腺癌、20例良性前列腺增生及2例慢性前列腺炎患者穫得可靠 ADC 值。與良性前列腺增生的 ADC 值[（1.72±0.28）×10-3 mm2/s]比較，前列腺癌的ADC 值明顯減低[（1.13±0.31）×10-3 mm2/s]，差異具有統計學意義（P＜0.001）。ROC 麯線上臨界點取1.31×10-3 mm2/s時，癌和非癌鑒彆診斷的敏感性為61.0%，特異性為85.7%。結論3.0 T DWI的ADC值有助于前列腺癌的鑒彆診斷。
목적：탐토3.0 T자공진미산가권성상（diffusion-weighted imaging，DWI）대전렬선암적진단화감별진단개치。방법응용3.0 T MR성상의대36례전렬선특이항원승고의유전렬선암적환자진행전렬선MRI고분변성상급단차격발EPI서렬적미산가권성상，b치분별취0、1000 s/mm2。장전렬선외주대이륙분구화분，관찰T2WI도급DWI도，병측정각구적표관미산계수（apparent diffusion coefficient，ADC）치。소유환자균행초성인도하계통천자활검증실，의병리결과장기분위전렬선암구、량성전렬선증생구급만성염증구。대소득수거진행통계분석。결과14례전렬선암、20례량성전렬선증생급2례만성전렬선염환자획득가고 ADC 치。여량성전렬선증생적 ADC 치[（1.72±0.28）×10-3 mm2/s]비교，전렬선암적ADC 치명현감저[（1.13±0.31）×10-3 mm2/s]，차이구유통계학의의（P＜0.001）。ROC 곡선상림계점취1.31×10-3 mm2/s시，암화비암감별진단적민감성위61.0%，특이성위85.7%。결론3.0 T DWI적ADC치유조우전렬선암적감별진단。
Objective To evaluate the diagnosis value of 3.0 T MR diffusion-weighted imaging in prostate cancer. Methods MR images were performed in 36 patients. High resolution T2WI and DWI were achieved at 3.0 T MR. The ADC maps were obtained with two b values (0 and 1000 s/mm2). Each peripheral zone was divided into 6 regions in ADC map and the ADC values were measured in each region by drawing the regions of interest(ROI). All the patients were proved by systemic ultrasound guided biopsy. Statistical analysis was performed on the date collected. Results Acceptable images for ADC measurement were obtained in 14 prostate cancer, 20 benign prostate hypertrophy(BPH) and 2 chronic prostatitis. The ADC value of prostate cancer[(1.13± 0.31)×10-3 mm2/s] was lower than BPH[(1.72±0.28)×10-3 mm2/s]. The difference between prostate cancer and BPH had statistical significance(P<0.001). With ROC cut point setting to 1.31×10-3 mm2/s, the diagnostic sensitivity and specificity for prostate cancer was 61.0% and 85.7% respectively. Conclusion ADC values measured from DWI at 3.0 T MR can be used in the differential diagnosis of prostate cancer.
