CAJ | 학술논문

MicroRNA（ miRNA）是一种非蛋白质的新型基因表达调控因子，广泛存在于真核生物中，参与了各种重要的细胞生物学过程。 miRNA在骨组织代谢过程中亦发挥了重要作用，研究人员对骨代谢相关miRNA的作用靶基因、信号通路等进行了大量研究，发现它们在调控骨组织代谢性疾病方面具有重要意义，因此笔者就miRNA的生物学特性、成骨相关miRNA、成软骨相关miRNA，骨吸收相关miRNA以及骨代谢性疾病相关miRNA的研究进展作一综述。骨代谢相关 miRNA的研究仍处于初级阶段，但是它在组织发育及疾病发生发展过程中具有明显的特异性表达，又结合其组织特异性及时序性的特点， miRNA就可以作为疾病的诊断标志物用于临床诊断中。
MicroRNA（ miRNA）시일충비단백질적신형기인표체조공인자，엄범존재우진핵생물중，삼여료각충중요적세포생물학과정。 miRNA재골조직대사과정중역발휘료중요작용，연구인원대골대사상관miRNA적작용파기인、신호통로등진행료대량연구，발현타문재조공골조직대사성질병방면구유중요의의，인차필자취miRNA적생물학특성、성골상관miRNA、성연골상관miRNA，골흡수상관miRNA이급골대사성질병상관miRNA적연구진전작일종술。골대사상관 miRNA적연구잉처우초급계단，단시타재조직발육급질병발생발전과정중구유명현적특이성표체，우결합기조직특이성급시서성적특점， miRNA취가이작위질병적진단표지물용우림상진단중。
MicroRNA ( miRNA) is a new type of non-protein factor, which regulates gene expression, widely exists in eukaryotic organisms, and participates in a variety of important cytobiology processes.miRNA also plays an important role in bone tissue metabolism.Through abundant researches on the target genes and signal pathways of bone metabolic related miRNA, the researchers discover that they play an important role in the regulation of bone metabolic diseases.Therefore, this paper reviews the research progress of the biological characteristics of miRNA, including osteogenic related miRNA, chondrogenic related miRNA, bone resorption related miRNA, and bone metabolic diseases related miRNA.Athough the study of bone metabolic related miRNA is still at a preliminary stage, it shows significant specific expression in the process of tissue development and the pathogenesis and development of diseases.Combining with its characteristics of tissue specificity and time sequence, miRNA can be used as a biomarker for disease diagnosis in clinical diagnosis.