CAJ | 학술논문

目的：护骨素（ OPG）和转化生长因子β1（ TGF-β1）与骨代谢密切相关。本研究调查女性血清OPG和TGF-β1水平与骨丢失率（ BLR）的关系，以及这两种细胞因子对BLR的影响。方法横断面研究465例健康成年女性，年龄35～80岁。测量血清OPG和TGF-β1水平，DXA骨密度仪测量腰椎、髋部和前臂远端的骨密度（ BMD）和BLR。结果各骨骼部位BLR与血清OPG呈负相关（r＝-0.122至-0.230， P＝0.007-0.000），与血清TGF-β1呈正相关（r＝0.245-0.365， P＝0.000）。调整年龄和BMI后，TGF-β1与腰椎和前臂超远端BLR的偏相关性仍然有显著意义。多元线性回归分析显示，OPG对BLR是一个负性决定因素，大约可以解释BLR变异的1.4％～3.7％；TGF-β1对BLR是一个正性决定因素，可以解释BLR变异的5.3％～13.3％。结论该研究揭示了成年女性循环中OPG和TGF-β1水平与骨丢失率的关系，提示TGF-β1和OPG水平变化与骨丢失率有关，TGF-β1可能是女性骨丢失率的独立决定因素。
목적：호골소（ OPG）화전화생장인자β1（ TGF-β1）여골대사밀절상관。본연구조사녀성혈청OPG화TGF-β1수평여골주실솔（ BLR）적관계，이급저량충세포인자대BLR적영향。방법횡단면연구465례건강성년녀성，년령35～80세。측량혈청OPG화TGF-β1수평，DXA골밀도의측량요추、관부화전비원단적골밀도（ BMD）화BLR。결과각골격부위BLR여혈청OPG정부상관（r＝-0.122지-0.230， P＝0.007-0.000），여혈청TGF-β1정정상관（r＝0.245-0.365， P＝0.000）。조정년령화BMI후，TGF-β1여요추화전비초원단BLR적편상관성잉연유현저의의。다원선성회귀분석현시，OPG대BLR시일개부성결정인소，대약가이해석BLR변이적1.4％～3.7％；TGF-β1대BLR시일개정성결정인소，가이해석BLR변이적5.3％～13.3％。결론해연구게시료성년녀성순배중OPG화TGF-β1수평여골주실솔적관계，제시TGF-β1화OPG수평변화여골주실솔유관，TGF-β1가능시녀성골주실솔적독립결정인소。
Objective To investigate the relationship between serum levels of OPG and TGF-β1 and bone loss rate ( BLR) in women, and to explore the effect of these 2 kinds of cytokines on BLR.Methods A cross-sectional study was performed.A total of 465 healthy adult women, aging from 35 to 80 years old were included in this study.The serum levels of OPG and TGF-β1 were determined.Bone mineral density ( BMD) and BLR of the lumbar vertebrae, the hip, and the distal forearm were detected using DXA.Results A negative correlation between BLR of all the parts and the serum level of OPG ( r=-0.122 to -0.230, all P=0.007-0.000) was observed, while a positive correlation between BLR and serum TGF-β1 (r=0.245-0.365, all P=0.000) existed.After adjusting for age and BMI, the significant correlation between serum TGF-β1 and BLR of the lumbar vertebrae and the ultradistal forearm still existed.Multiple linear regression analysis showed that serum OPG was a negative determinant of BLR, explaining 1.4-3.7%of BLR variation.Serum TGF-β1 was a positive determinant of BLR, which could explain 5.3-13.3%BLR variation.Conclusion This study has revealed the relationship between serum levels of OPG and TGF-β1 and BLR in adult women, which indicates that the changes of TGF-β1 and OPG levels are associated with BLR, and TGF-β1 may be an independent determinant for BLR in women.