CAJ | 학술논문

目的：探讨孕早期高蛋白质膳食(HPD)对子代肥胖和肉碱酰基转移酶1(CPT1)表达的影响，寻找肥胖防治的靶标和合理的孕期膳食。方法孕早期大鼠分别给予HPD和标准膳食(SD)，其后代分别为高蛋白质组(HP)和对照组(CON)，SD喂养至成年，高脂膳食诱导肥胖,FQ-PCR法检测CPT1 mRNA的水平。结果与对照组相比，HPD大鼠子代的体重持续降低(P<0.05)，CPT1 mRNA水平持续升高。结论孕早期HPD可通过程序性升高子代CPT1 mRNA的水平，降低肥胖的发生。
목적：탐토잉조기고단백질선식(HPD)대자대비반화육감선기전이매1(CPT1)표체적영향，심조비반방치적파표화합리적잉기선식。방법잉조기대서분별급여HPD화표준선식(SD)，기후대분별위고단백질조(HP)화대조조(CON)，SD위양지성년，고지선식유도비반,FQ-PCR법검측CPT1 mRNA적수평。결과여대조조상비，HPD대서자대적체중지속강저(P<0.05)，CPT1 mRNA수평지속승고。결론잉조기HPD가통과정서성승고자대CPT1 mRNA적수평，강저비반적발생。
Objective To study the effects of high protein diet(HPD) during early pregnancy on offspring carnitine acyltransferase 1 (CPT1) mRNA, and find out optimal pregnant diet. Methods Rats were fed with a HPD and standard diet (SD) during early pregnancy, respectively. Male offspring were high protein (HP) and control (CON) group, respectively. Offspring were fed with a SD until adult. Rats were fed with high fat diet to induce obesity. CPT1 gene was analyzed by FQ-PCR. Results Body weight were decreased and CPT1 mRNA were increased in HP group (P<0.05). Conclusion HPD during early pregnancy can prevent offspring from obesity by mediating lipolysis.