中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2013年
36期
27-28
,共2页
类风湿关节炎%临床%类风湿因子%C反应蛋白%抗环瓜氨酸肽抗体
類風濕關節炎%臨床%類風濕因子%C反應蛋白%抗環瓜氨痠肽抗體
류풍습관절염%림상%류풍습인자%C반응단백%항배과안산태항체
Rheumatoid arthritis%Clinical%RF%CRP%Anti-CCP antibodies
目的：通过分析类风湿关节炎的临床资料及进行类风湿因子(RF)、C反应蛋白(CRF)及抗环瓜氨酸肽抗体（抗CCP抗体）的检查，探讨RF、CRP及抗CCP抗体联合检测在诊断类风湿关节炎患者的临床应用价值。方法对本院的115例类风湿关节炎的患者及131例非类风湿性患者的血清，用酶联免疫吸附试验检测抗CCP抗体、免疫比浊法对RF、CRP进行定量检测，然后对RF、CRP及抗CCP抗体检查结果进行分析。结果类风湿关节炎组RF、CRP及抗CCP抗体检测的阳性率显著高于非类风湿关节炎组，抗CCP抗体对类风湿关节炎的敏感性为64.5%， CRP对类风湿关节炎的敏感性为69.9%， RF对类风湿关节炎的敏感性为60.5%，略低于抗CCP抗体和CRP；RF对类风湿关节炎的特异性为79.3%，抗CCP抗体的特异性最高94.0%， CRP较低为55%；抗CCP抗体和RF、CRP联合检测时对RA诊断的敏感性为73.5%，特异性为98.9%。经统计学检验， RF、CRP及抗CCP抗体联合检测的灵敏性与单独应用时差异无统计学意义；RF、CRP及抗CCP抗体联合检测特异性比抗CCP抗体、RF、CRP高，差异有统计学意义。结论临床单独将RF、CRP或抗CCP抗体的检查用于类风湿关节炎的诊断敏感性和特异性一般，为提高类风湿关节炎诊断的敏感性和特异性，应该将RF、CRP和抗CCP抗体检测进行联合应用。
目的：通過分析類風濕關節炎的臨床資料及進行類風濕因子(RF)、C反應蛋白(CRF)及抗環瓜氨痠肽抗體（抗CCP抗體）的檢查，探討RF、CRP及抗CCP抗體聯閤檢測在診斷類風濕關節炎患者的臨床應用價值。方法對本院的115例類風濕關節炎的患者及131例非類風濕性患者的血清，用酶聯免疫吸附試驗檢測抗CCP抗體、免疫比濁法對RF、CRP進行定量檢測，然後對RF、CRP及抗CCP抗體檢查結果進行分析。結果類風濕關節炎組RF、CRP及抗CCP抗體檢測的暘性率顯著高于非類風濕關節炎組，抗CCP抗體對類風濕關節炎的敏感性為64.5%， CRP對類風濕關節炎的敏感性為69.9%， RF對類風濕關節炎的敏感性為60.5%，略低于抗CCP抗體和CRP；RF對類風濕關節炎的特異性為79.3%，抗CCP抗體的特異性最高94.0%， CRP較低為55%；抗CCP抗體和RF、CRP聯閤檢測時對RA診斷的敏感性為73.5%，特異性為98.9%。經統計學檢驗， RF、CRP及抗CCP抗體聯閤檢測的靈敏性與單獨應用時差異無統計學意義；RF、CRP及抗CCP抗體聯閤檢測特異性比抗CCP抗體、RF、CRP高，差異有統計學意義。結論臨床單獨將RF、CRP或抗CCP抗體的檢查用于類風濕關節炎的診斷敏感性和特異性一般，為提高類風濕關節炎診斷的敏感性和特異性，應該將RF、CRP和抗CCP抗體檢測進行聯閤應用。
목적：통과분석류풍습관절염적림상자료급진행류풍습인자(RF)、C반응단백(CRF)급항배과안산태항체（항CCP항체）적검사，탐토RF、CRP급항CCP항체연합검측재진단류풍습관절염환자적림상응용개치。방법대본원적115례류풍습관절염적환자급131례비류풍습성환자적혈청，용매련면역흡부시험검측항CCP항체、면역비탁법대RF、CRP진행정량검측，연후대RF、CRP급항CCP항체검사결과진행분석。결과류풍습관절염조RF、CRP급항CCP항체검측적양성솔현저고우비류풍습관절염조，항CCP항체대류풍습관절염적민감성위64.5%， CRP대류풍습관절염적민감성위69.9%， RF대류풍습관절염적민감성위60.5%，략저우항CCP항체화CRP；RF대류풍습관절염적특이성위79.3%，항CCP항체적특이성최고94.0%， CRP교저위55%；항CCP항체화RF、CRP연합검측시대RA진단적민감성위73.5%，특이성위98.9%。경통계학검험， RF、CRP급항CCP항체연합검측적령민성여단독응용시차이무통계학의의；RF、CRP급항CCP항체연합검측특이성비항CCP항체、RF、CRP고，차이유통계학의의。결론림상단독장RF、CRP혹항CCP항체적검사용우류풍습관절염적진단민감성화특이성일반，위제고류풍습관절염진단적민감성화특이성，응해장RF、CRP화항CCP항체검측진행연합응용。
Objective To analyze the clinical data of rheumatoid arthritis and conduct RF, CPR and anti-CCP antibodies checks, and explore the clinical value of RF, CPR and anti-CCP antibodies in the diagnosis of patients with rheumatoid arthritis. Methods 115 cases of our hospital patients with rheumatoid arthritis and 131 cases of non-rheumatoid patient's serum by enzyme-linked immunosorbent assay detection of anti-CCP antibodies , immune turbidimetric method for RF, CPR for quantitative detection , and then RF, CPR and anti-CCP antibody test results were analyzed . Results Rheumatoid arthritis group RF, CPR and anti-CCP antibody positive rate was significantly higher than non-rheumatoid arthritis group , anti-CCP antibodies in rheumatoid arthritis with a sensitivity of 64.5%, CRP rheumatoid arthritis sensitivity was 69.9%, RF sensitivity of rheumatoid arthritis was 60.5%, slightly lower anti-CCP antibodies and CRP;RF rheumatoid arthritis specificity of 79.3%, specificity of anti-CCP antibodies highest 94.0%, CRP was 55%lower;anti-CCP and RF, CRP combined detection sensitivity for the diagnosis of RA was 73.5%, specificity of 98.9%. Comparing RF, CPR and anti-CCP antibody combined with RF, CPR and anti-CCP lone, there was no significant difference in the detection sensitivity .But the specificity is higher, and there are significant difference. Conclusion If we separated the clinical of RF, CRP or anti-CCP antibodies in rheumatoid arthritis check the diagnostic sensitivity and specificity is general.To improve the diagnosis of rheumatoid arthritis, sensitivity and specificity, we should conduct the combine of RF, CRP and anti-CCP antibody detection into applications.
