CAJ | 학술논문

目的：探讨促肾上腺激素释放激素(corticotropin releasing hormone, CRH)、雌二醇(estradiol, E2)及孕激素(progesterone, P)在妊娠期间的浓度变化及其在早产中的预测作用。方法选取正常妊娠组孕妇54例,先兆早产组孕妇54例,采集外周静脉血分离血浆,用免疫化学发光法测定E2、P,放射免疫法测定CRH水平。结果①正常妊娠血CRH均值28~33周组与>37周组比,明显低于>37周组,经t检验P<0.05；血E2各组间均值经t检验P>0.05,差异无统计学意义；血P各组均值,28~33周组明显高于>37周组,经t检验P<0.05,差异有统计学意义,其余各组差异无统计学意义。②正常妊娠组和先兆早产组在妊娠28~33周血CRH分别为(68.23±13.34)ng/L和(298.42±162.78)ng/L；在34~36周分别为(132.75±126.3) ng/L和(354.42±50.46) ng/L,经t检验, P值均<0.05,差异有统计学意义。正常妊娠组和先兆早产组血E2在28~33周分别为(128.72±50.83)μg/L和(152.94±31.7)μg/L；在34~36周分别为(136.24±62.41)μg/L和(173.58±92.3)μg/L,两组均值经t检验, P值均<0.05,差异无统计学意义。正常妊娠组和先兆早产组血P在28~33周分别为(523.52±105.43)μg/L和(353.21±52.21)μg/L,34~36周(483.24±113.52)μg/L和(310.25±83.02)μg/L,差异有统计学意义。结论血P在妊娠晚期各孕周组间变化较为明显,妊娠>37周之后明显下降。妊娠晚期正常妊娠组中的血浆CRH值随着孕周增加而逐渐升高,而血E2值无明显变化。
목적：탐토촉신상선격소석방격소(corticotropin releasing hormone, CRH)、자이순(estradiol, E2)급잉격소(progesterone, P)재임신기간적농도변화급기재조산중적예측작용。방법선취정상임신조잉부54례,선조조산조잉부54례,채집외주정맥혈분리혈장,용면역화학발광법측정E2、P,방사면역법측정CRH수평。결과①정상임신혈CRH균치28~33주조여>37주조비,명현저우>37주조,경t검험P<0.05；혈E2각조간균치경t검험P>0.05,차이무통계학의의；혈P각조균치,28~33주조명현고우>37주조,경t검험P<0.05,차이유통계학의의,기여각조차이무통계학의의。②정상임신조화선조조산조재임신28~33주혈CRH분별위(68.23±13.34)ng/L화(298.42±162.78)ng/L；재34~36주분별위(132.75±126.3) ng/L화(354.42±50.46) ng/L,경t검험, P치균<0.05,차이유통계학의의。정상임신조화선조조산조혈E2재28~33주분별위(128.72±50.83)μg/L화(152.94±31.7)μg/L；재34~36주분별위(136.24±62.41)μg/L화(173.58±92.3)μg/L,량조균치경t검험, P치균<0.05,차이무통계학의의。정상임신조화선조조산조혈P재28~33주분별위(523.52±105.43)μg/L화(353.21±52.21)μg/L,34~36주(483.24±113.52)μg/L화(310.25±83.02)μg/L,차이유통계학의의。결론혈P재임신만기각잉주조간변화교위명현,임신>37주지후명현하강。임신만기정상임신조중적혈장CRH치수착잉주증가이축점승고,이혈E2치무명현변화。
Objective To discuss the concentration changes of Corticotropin Releasing Hormone(CRH), Estradiol (E2), and Progesterone (P) during the third trimester and analyze its predictive role in preterm. Methods 54 pregnant women of threatened prematurity were enrolled as the threatened prematurity group, 54 normal pregnant women were selected as normal pregnant group. Three milliliters of venous blood were taken from all of the women. The levels of E2, P were detected by chemiluminescence immunoassay (CLIA), CRH by radioimmunoassay (RIA). Results The mean plasma CRH of 28~33 weeks group was significantly lower than>37 weeks group in the normal pregnant group (P<0.05). There was no significant deference in each groups about the E2 (P>0.05). The mean plasma P of 28~33 weeks group was significantly higher than>37 weeks group (P<0.05). In 28~33 weeks the plasma CRH were respectively (68.23±13.34)ng/L and (298.42±162.78 ) ng/L in the group of normal pregnant and the group of threatened prematurity. The same as (132.75±126.3) ng/L and (354.42±50.46) ng/L in 34~36 weeks. There was a significant difference in the plasma CRH in the two groups (P<0.05). In 28~33 weeks the plasma CRH were respectively (68.23±13.34)ng/L and (298.42±162.78 ) ngl/L in the group of normal pregnant and the group of threatened prematurity. The same as (132.75±126.3) ng/L and (354.42±50.46) ng/L in 34-36 weeks. There was a significant difference in the plasma CRH in the two groups (P<0.05). In 28~33 weeks the plasma E2 were respectively (128.72±50.83)μg/L and (152.94±31.7)μg/L in the group of normal pregnant and the group of threatened prematurity. The same as (136.24±62.41)μg/L and (173.58±92.3)μg/L in 34~36 weeks. There was no significant difference in the plasma E2 in the two groups(P>0.05). In 28-33 weeks the plasma P were respectively (523.52±105.43)μg/L and (353.21±52.21)μg/L in the group of normal pregnant and the group of threatened prematurity. The same as (483.24±113.52)μg/L and (310.25±83.02)μg/L in 34~36 weeks. There was a significant difference in the plasma E2 in the two groups (P<0.05). Conclusion The plasma P changed obviously in the third trimester. It was declined significantly after the 37th weeks. In the trimester the plasma CRH gradually increased with the increasing gestational age. But there was no significant changes in E2. CRH may be an important factor in onset of delivery.