中国卒中杂志
中國卒中雜誌
중국졸중잡지
CHINESE JOURNAL OF STROKE
2014年
1期
38-42
,共5页
抑郁症%卒中后抑郁%谷氨酸%抗抑郁药
抑鬱癥%卒中後抑鬱%穀氨痠%抗抑鬱藥
억욱증%졸중후억욱%곡안산%항억욱약
Depression%Post-stroke depression%Glutamate%Antidepressant
卒中后抑郁（post-stroke depression，PSD）是卒中后常见的神经精神症状之一，以心境低落、兴趣下降为主要特征，不仅影响患者神经功能的康复，而且显著增加卒中病死率。其发病机制尚未明确，伴随离子型谷氨酸受体拮抗剂氯胺酮的快速抗抑郁作用的出现，谷氨酸（glutamate，Glu）能神经系统在抑郁症及PSD中的作用日益突出，也为抗抑郁治疗带来新的契机。
卒中後抑鬱（post-stroke depression，PSD）是卒中後常見的神經精神癥狀之一，以心境低落、興趣下降為主要特徵，不僅影響患者神經功能的康複，而且顯著增加卒中病死率。其髮病機製尚未明確，伴隨離子型穀氨痠受體拮抗劑氯胺酮的快速抗抑鬱作用的齣現，穀氨痠（glutamate，Glu）能神經繫統在抑鬱癥及PSD中的作用日益突齣，也為抗抑鬱治療帶來新的契機。
졸중후억욱（post-stroke depression，PSD）시졸중후상견적신경정신증상지일，이심경저락、흥취하강위주요특정，불부영향환자신경공능적강복，이차현저증가졸중병사솔。기발병궤제상미명학，반수리자형곡안산수체길항제록알동적쾌속항억욱작용적출현，곡안산（glutamate，Glu）능신경계통재억욱증급PSD중적작용일익돌출，야위항억욱치료대래신적계궤。
Post-stroke depression (PSD) is one of the most common neuropsychiatric complications after stroke that is characterized by depressed mood and loss interest. It can not only affect the neurological rehabilitation, but also signiifcantly increase the mortality of patients. However, the pathogenesis is not clear. Glutamate system plays an important role in depression and PSD and brings new opportunities for treatment along with the appearance of rapid antidepressant ketamine which is the antagonist of an ionotropic glutamate receptor.
