CAJ | 학술논문

目的：探讨补肾健脾中药方对去卵巢大鼠血清SOD和MDA的影响。方法48只6月龄的雌性SD大鼠随机分为正常空白组、模型组、中药组、西药组。治疗12周后，收集左侧股骨、血清分别行BMD测量和SOD、MDA检测。结果最后纳入研究动物40只。股骨BMD值：模型组低于正常空白组（ P＜0.01）；观察组、对照组分别与模型组比较，差异有统计学意义（ P＜0.05）。在SOD方面，观察组、对照组的SOD值均比模型组高，三者比较，有统计学意义（P＜0.05）。在MDA方面，观察组、对照组的MDA值均比模型组低，三者比较，有统计学意义（P＜0.05）。结论补肾健脾中药康方具有提高去卵巢大鼠BMD的作用；能够提高血清中SOD的含量，同时减低MDA含量，在一定的程度上清理自由基，达到防治骨质疏松症的目的。
목적：탐토보신건비중약방대거란소대서혈청SOD화MDA적영향。방법48지6월령적자성SD대서수궤분위정상공백조、모형조、중약조、서약조。치료12주후，수집좌측고골、혈청분별행BMD측량화SOD、MDA검측。결과최후납입연구동물40지。고골BMD치：모형조저우정상공백조（ P＜0.01）；관찰조、대조조분별여모형조비교，차이유통계학의의（ P＜0.05）。재SOD방면，관찰조、대조조적SOD치균비모형조고，삼자비교，유통계학의의（P＜0.05）。재MDA방면，관찰조、대조조적MDA치균비모형조저，삼자비교，유통계학의의（P＜0.05）。결론보신건비중약강방구유제고거란소대서BMD적작용；능구제고혈청중SOD적함량，동시감저MDA함량，재일정적정도상청리자유기，체도방치골질소송증적목적。
Objective To investigate the effect of the tonifying the kidney and strengthening the spleen prescription on serum super oxide dismutase ( SOD) and malondialdehyde ( MDA) in ovariectomized rats.Methods Forty-eight 6-month female SD rats were randomly divided into 4 groups ( n=12 ): normal group, ovariectomized group, control group, and observation group. After 12-week treatment, bone mineral density ( BMD) of the left femur was detected, and the serum levels of SOD and MDA were also detected.Results Forty rats were included in the study finally.BMD of the femur in normal group was higher than that in ovariectomized group (P<0.01).Significant difference of BMD of the femur in observation group and control group was observed compared with that in ovariectomized group ( P <0.05 ) , respectively.The serum level of SOD in both observation group and control group was higher than that in ovariectomized group, and significant difference was observed among 3 groups (P<0.05). On the contrary, the serum level of MDA in both observation group and control group was lower than that in ovariectomized group, and significant difference was also observed among 3 groups (P<0.05).Conclusion The tonifying the kidney and strengthening the spleen prescription can improve BMD in ovariectomized rats, improve the serum level of SOD, and reduce the serum level of MDA, which can clear up free radicals to some extent, achieving the purpose of preventing and treating osteoporosis.