CAJ | 학술논문

颅脑创伤后产生的非感染性的神经炎症反应是一个重要的继发性病理生理反应。 Toll样受体（ TLRs）不仅可以介导感染性的炎症反应，还可以识别内源性配体介导非感染性的炎症反应。而TLRs在颅脑创伤后神经炎症反应中作用的研究目前还不多见，本文就颅脑创伤后神经炎症以及TLRs的表达分布、作用效应、信号通路等方面进行简要综述。
로뇌창상후산생적비감염성적신경염증반응시일개중요적계발성병리생리반응。 Toll양수체（ TLRs）불부가이개도감염성적염증반응，환가이식별내원성배체개도비감염성적염증반응。이TLRs재로뇌창상후신경염증반응중작용적연구목전환불다견，본문취로뇌창상후신경염증이급TLRs적표체분포、작용효응、신호통로등방면진행간요종술。
Non-infectious neuroinflammation induced by activated microglia after traumatic brain injury is an important secondary patho-physiological response .Toll like receptors on immune cells not only mediate infectious inflammation,but also mediate non-infectious inflammation.The studies about the effect of Toll like receptors on neuroinflammation following traumatic brain injury are rare at present ,and how to effectively modulate neuroinflam-mation mediated by Toll like receptors signaling pathway is an important issue .The authors review the current situa-tion and research progress about this issue .