CAJ | 학술논문

各种来源的间充质干细胞（ MSC）除满足国际细胞治疗协会（ ISCT）规定的要求外，在表面标记物、增殖、分化、迁移、生物学功能方面有其差异性，骨髓MSC研究最早，最为透彻，但其增殖效率低，易被污染等劣势限制了其应用；脂肪、脐血、脐带、羊水、胎盘来源的MSC取材方便，传代能力强，免疫反应低，被污染的概率较小，无伦理学限制等优点逐渐被人们重视，且利用不同MSC的优劣势将其应用于不同的领域。笔者通过查阅国内外相关文献，从细胞表面标记物，增殖、分化、迁移能力，以及功能方面进行分析总结，初步探讨了各种来源的间充质干细胞的优缺点，为今后临床选取合适理想的种子细胞提供帮助。
각충래원적간충질간세포（ MSC）제만족국제세포치료협회（ ISCT）규정적요구외，재표면표기물、증식、분화、천이、생물학공능방면유기차이성，골수MSC연구최조，최위투철，단기증식효솔저，역피오염등열세한제료기응용；지방、제혈、제대、양수、태반래원적MSC취재방편，전대능력강，면역반응저，피오염적개솔교소，무윤리학한제등우점축점피인문중시，차이용불동MSC적우열세장기응용우불동적영역。필자통과사열국내외상관문헌，종세포표면표기물，증식、분화、천이능력，이급공능방면진행분석총결，초보탐토료각충래원적간충질간세포적우결점，위금후림상선취합괄이상적충자세포제공방조。
Mesenchymal stem cells ( MSC) meet the requirements of International Society for Cellular Ther-apy and also have variability in surface markers,proliferation,differentiation,migration,and biological function. Bone marrow MSC have been studied early and got great achievement ,their proliferation is lowly efficient and they are easily contaminated ,resulting in limited application .MSC derived from fat ,umbilical cord blood ,umbilical cord , amniotic fluid,placenta have advantages of easy access ,strong passage ability,low immune response,low probability of being contaminated and no ethics restrictions ,etc.Thus,MSC from different sources are attached more impor-tance.By reviewing the relevant literatures and analyzing the characteristics of MSC from the fields of cell surface markers,proliferation,differentiation,migration,and function,the authors primarily explore the advantages and disad-vantages of MSC from a variety of sources ,so as to help doctors to select appropriate seed cells in clinical practice .