CAJ | 학술논문

肺纤维化是由多种病因引起的弥漫性肺部炎性疾病的共同结局.肺纤维化疾病包括特发性肺纤维化,结节病、尘肺、过敏性肺炎、药物和放射线导致的肺纤维化以及与胶原血管病有关的肺纤维化等.肺纤维化以大量成纤维细胞聚集、细胞外基质沉积并伴有炎症和损伤所致组织结构破坏为特征.其病理特点包括肺组织间质细胞增殖、细胞外基质增生沉积及肺实质重构,其发病率和病死率各不相同.目前大部分的研究认为肺成纤维细胞是促进细胞外基质沉积的主要细胞,然而最近的研究证实纤维细胞亦能够促进肺纤维化的演进.纤维细胞是骨髓来源的间叶祖细胞,是成纤维细胞、肌成纤维细胞及脂肪细胞的前体细胞,它能够表达与白细胞、单核巨噬细胞和成纤维细胞相关的细胞标记.本文将简单讨论纤维细胞在肺纤维化发病机制中的作用.
폐섬유화시유다충병인인기적미만성폐부염성질병적공동결국.폐섬유화질병포괄특발성폐섬유화,결절병、진폐、과민성폐염、약물화방사선도치적폐섬유화이급여효원혈관병유관적폐섬유화등.폐섬유화이대량성섬유세포취집、세포외기질침적병반유염증화손상소치조직결구파배위특정.기병리특점포괄폐조직간질세포증식、세포외기질증생침적급폐실질중구,기발병솔화병사솔각불상동.목전대부분적연구인위폐성섬유세포시촉진세포외기질침적적주요세포,연이최근적연구증실섬유세포역능구촉진폐섬유화적연진.섬유세포시골수래원적간협조세포,시성섬유세포、기성섬유세포급지방세포적전체세포,타능구표체여백세포、단핵거서세포화성섬유세포상관적세포표기.본문장간단토론섬유세포재폐섬유화발병궤제중적작용.
Pulmonary fibrosis encompasses a heterogeneous group of disorders characterized by replacement of the lung parenchyma with scar tissue.Pulmonary fibrotic diseases include idiopathic pulmonary fibrosis,scleroderma,pneumoconiosis,hypersensitivity pneumonitis,drug and radiation induced lung fibrosis and pulmonary fibrosis associated with collagen vascular disease.Pulmonary fibrosis is characterized by the gathering of a large number of fibroblasts,extracellular matrix deposition associated with inflammation and damage,and its pathological features include interstitial lung tissue cell proliferation,the hyperplasia and deposition of extracellular matrix,and pulmonary parenchyma remodeling.Although there are several cellular types that are involved in the pathogenesis of pulmonary fibrosis,the resident lung fibroblast has been viewed traditionally as the primary cell involved in promoting the deposition of extracellular matrix that culminates in pulmonary fibrosis.However,recent findings demonstrate that the fibrocyte can contribute to the evolution of pulmonary fibrosis.Fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of cell-surface markers related to leukocytes,hematopoietic progenitor cells,and fibroblasts.Fibrocytes are capable of differentiating into fibroblasts,myofibroblasts,and adipocytes.This article reviews the critical role of fibrocytes in the pathogenesis of pulmonary fibrosis.