CAJ | 학술논문

目的观察鼠神经生长因子(mNGF)治疗带状疱疹的临床疗效.方法将64例带状疱疹患者,按随机数字表法分为治疗组和对照组,每组32例,两组均给予常规治疗,治疗组在常规治疗的基础上应用mNGF肌肉注射,每日30 μg,共14d,每5d观察疼痛变化情况,共观察1个月.结果治疗组疼痛减轻时间、疼痛消失时间分别为(4.36±2.01)、(12.29±1.98)d,均短于对照组的(7.23±3.57)、(20.36±2.24)d,差异有统计学意义(t=5.21、8.37,P＜0.01)；治疗组总有效率为96.9％(31/32),显著高于对照组的71.9％(23/32),差异有统计学意义(P＜0.05).结论 mNGF配合常规治疗能明显缩短带状疱疹受累神经的修复过程,改善临床症状,并且不良反应少.
목적 관찰서신경생장인자(mNGF)치료대상포진적림상료효.방법 장64례대상포진환자,안수궤수자표법분위치료조화대조조,매조32례,량조균급여상규치료,치료조재상규치료적기출상응용mNGF기육주사,매일30 μg,공14d,매5d관찰동통변화정황,공관찰1개월.결과 치료조동통감경시간、동통소실시간분별위(4.36±2.01)、(12.29±1.98)d,균단우대조조적(7.23±3.57)、(20.36±2.24)d,차이유통계학의의(t=5.21、8.37,P＜0.01)；치료조총유효솔위96.9％(31/32),현저고우대조조적71.9％(23/32),차이유통계학의의(P＜0.05).결론 mNGF배합상규치료능명현축단대상포진수루신경적수복과정,개선림상증상,병차불량반응소.
Objective To observe the effect of mouse nerve growth factor (mNGF) on treating herpes zoster.Methods The 64 patients with herpes zoster were divided into treatment group and control group by random digits table with 32 cases each.The control group received only routine treatment,the treatment group based on routine treatment combined with mNGF 30 μ g,both groups were treated 14 days.Pain changes of two groups were observed in once every 5 days,a total of 1 month.Results The times of pain to lessen and the pain to vanish of treatment group were (4.36 ± 2.01) and (12.29 ± 1.98) d,those of control group were (7.23 ±3.57) and (20.36 ±2.24) d,there were significant differences (t =5.21 and 8.37,P ＜0.01).The effective rate of treatment group was significantly higher than that of control group [96.9％(31/32) vs.71.9％(23/32),P＜0.05].Conclusion mNGF combined with routine treatment can significantly shorten the course of nerve injury and improve the prognosis with few adverse reactions.