CAJ | 학술논문

目的对乙型肝炎相关慢加急性肝衰竭患者并发抑郁症的情况进行调查，并分析其发病的影响因素。方法采用配对设计的病例对照研究，选择乙型肝炎相关慢加急性肝衰竭患者40例、相匹配的乙型肝炎肝硬化失代偿期患者40例及正常对照40例。调查表采用国际通用汉密尔顿抑郁量表24项版（ HAMD）。结果乙型肝炎相关慢加急性肝衰竭患者HAMD评分为11.48±9.54，乙型肝炎肝硬化失代偿期患者HAMD评分为10.50±7.33，正常对照 HAMD 评分为5.20±5.35，三者相比具有显著差异（ P ＜0.001）。教育水平、焦虑、病情的严重程度、睡眠质量是抑郁的预测因素。结论 Child-Pugh评分分级较高的肝衰竭患者患抑郁症的风险升高，同时睡眠质量不好、焦虑、受教育水平较低与较高的抑郁风险相关。有必要对此类患者进行心理疏导。
목적대을형간염상관만가급성간쇠갈환자병발억욱증적정황진행조사，병분석기발병적영향인소。방법채용배대설계적병례대조연구，선택을형간염상관만가급성간쇠갈환자40례、상필배적을형간염간경화실대상기환자40례급정상대조40례。조사표채용국제통용한밀이돈억욱량표24항판（ HAMD）。결과을형간염상관만가급성간쇠갈환자HAMD평분위11.48±9.54，을형간염간경화실대상기환자HAMD평분위10.50±7.33，정상대조 HAMD 평분위5.20±5.35，삼자상비구유현저차이（ P ＜0.001）。교육수평、초필、병정적엄중정도、수면질량시억욱적예측인소。결론 Child-Pugh평분분급교고적간쇠갈환자환억욱증적풍험승고，동시수면질량불호、초필、수교육수평교저여교고적억욱풍험상관。유필요대차류환자진행심리소도。
Objective To determine whether depression in patients with HBV-related ACLF differ from those with HBV-related liver cirrhosis and identify which factors could predict depression in liver patients . Methods This is a paired case-control study .A total of 80 inpatients ( 40 cases for HBV-related ACLF and 40 paired controls for HBV-related liver cirrhosis ) as well as 40 paired healthy controls were studied .The Hamilton Rating Scale for Depression ( HAMD ) was used to assess depression .Results Depression in patients with HBV-related ACLF(HAMD score 11.48 ±9.54)was significantly higher than in healthy controls (HAMD score 5.20 ± 5.35),but was equivalent to patients with HBV-related liver cirrhosis(10.50 ±7.33).Education level,anxiety, severity of liver disease , and sleep quality were predictors of depression .Conclusion Patients with HBV-related ACLF classified as higher child-pugh′s stage are at increased risk of depression .Poor sleep quality ,anxiety,and lower educational level were associated with elevated depression .