中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
9期
3824-3827
,共4页
邓彬%丁岩冰%张艳青%王梅%王远志%吴大成%庞磊%吴克艳%卜平
鄧彬%丁巖冰%張豔青%王梅%王遠誌%吳大成%龐磊%吳剋豔%蔔平
산빈%정암빙%장염청%왕매%왕원지%오대성%방뢰%오극염%복평
胃肿瘤%T淋巴细胞,调节性%缺氧诱导因子1,α亚基%免疫
胃腫瘤%T淋巴細胞,調節性%缺氧誘導因子1,α亞基%免疫
위종류%T림파세포,조절성%결양유도인자1,α아기%면역
Stomach neoplasms%T-Lymphocytes,regulatory%Hypoxia-inducible factor 1,alpha subunit%Immunity
目的探讨胃癌组织中调节性T细胞浸润和缺氧诱导因子-1α( HIF-1α)的表达及联合检测对预后的预测价值。方法收集2006年12月至2007年12月90例胃癌患者临床及随访资料。免疫组织化学染色检测90例胃癌及癌旁组织内Foxp3和HIF-1α的表达。结果胃癌组织内Foxp3计数显著高于癌旁组织(10.93±7.49 vs.4.10±2.03,t=9.19,P<0.01);胃癌组织内HIF-1α评分显著高于癌旁组织(6.48±3.09 vs.2.87±1.72,t=10.80, P<0.01)。胃癌组织内Foxp3和HIF-1α的表达呈显著正相关( r =0.661, P <0.001);HIF-1α表达与肿瘤浸润深度(P=0.015)和肿瘤临床分期(P=0.001)相关,Foxp3表达与肿瘤临床分期( P=0.012)相关;Foxp3和HIF-1α均低表达的27例患者中位生存期显著长于Foxp3和HIF-1α均高表达的41例患者( P=0.005)。结论联合检测Foxp3和HIF-1α的表达可有效的预测胃癌预后。
目的探討胃癌組織中調節性T細胞浸潤和缺氧誘導因子-1α( HIF-1α)的錶達及聯閤檢測對預後的預測價值。方法收集2006年12月至2007年12月90例胃癌患者臨床及隨訪資料。免疫組織化學染色檢測90例胃癌及癌徬組織內Foxp3和HIF-1α的錶達。結果胃癌組織內Foxp3計數顯著高于癌徬組織(10.93±7.49 vs.4.10±2.03,t=9.19,P<0.01);胃癌組織內HIF-1α評分顯著高于癌徬組織(6.48±3.09 vs.2.87±1.72,t=10.80, P<0.01)。胃癌組織內Foxp3和HIF-1α的錶達呈顯著正相關( r =0.661, P <0.001);HIF-1α錶達與腫瘤浸潤深度(P=0.015)和腫瘤臨床分期(P=0.001)相關,Foxp3錶達與腫瘤臨床分期( P=0.012)相關;Foxp3和HIF-1α均低錶達的27例患者中位生存期顯著長于Foxp3和HIF-1α均高錶達的41例患者( P=0.005)。結論聯閤檢測Foxp3和HIF-1α的錶達可有效的預測胃癌預後。
목적탐토위암조직중조절성T세포침윤화결양유도인자-1α( HIF-1α)적표체급연합검측대예후적예측개치。방법수집2006년12월지2007년12월90례위암환자림상급수방자료。면역조직화학염색검측90례위암급암방조직내Foxp3화HIF-1α적표체。결과위암조직내Foxp3계수현저고우암방조직(10.93±7.49 vs.4.10±2.03,t=9.19,P<0.01);위암조직내HIF-1α평분현저고우암방조직(6.48±3.09 vs.2.87±1.72,t=10.80, P<0.01)。위암조직내Foxp3화HIF-1α적표체정현저정상관( r =0.661, P <0.001);HIF-1α표체여종류침윤심도(P=0.015)화종류림상분기(P=0.001)상관,Foxp3표체여종류림상분기( P=0.012)상관;Foxp3화HIF-1α균저표체적27례환자중위생존기현저장우Foxp3화HIF-1α균고표체적41례환자( P=0.005)。결론연합검측Foxp3화HIF-1α적표체가유효적예측위암예후。
Objective To explore the clinical value of hypoxia inducible factor-1α( HIF-1α) and regulatory T cells(Tregs)in gastric carcinoma.Methods Clinicopathological characteristics and follow up data of 90 patients with gastric carcinoma were collected .We analyzed the expression of Foxp 3 and HIF-1αin gastric carcinoma via immunohistochemistry.Results The number of Foxp3 + cells and score of HIF-1αin gastric carcinoma was significantly higher than that in adjacent tissues (10.93 ±7.49 vs.4.10 ±2.03,t=9.19,P<0.01 and 6.48 ±3.09 vs.2.87 ±1.72 , t =10.80 , P <0.01 ) .A positive correlation between the number of Foxp 3 + cells and HIF-1αexpression was observed in gastric carcinoma .There was an increase in positive rate of HIF-1αwith depth of tumor invasion(P=0.015).A similar trend was also found between the expression of HIF-1α(P=0.001)or Foxp3(P=0.012 ) and advancing tumor stage .The median survival of patients with low expression of Foxp 3 and HIF-1α( n=27)was significantly longer than those with high expression (n=41)(P=0.005).Conclusion Combined detection of Foxp3 and HIF-1αmay predict the prognosis of gastric carcinoma .