CAJ | 학술논문

目的通过对2型糖尿病患者的泪膜和眼表病变进行临床检测,探讨2型糖尿病与泪膜和角结膜上皮改变的相关性.方法对25例(50只眼)糖尿病住院患者和25例(50只眼)无糖尿病者(年龄匹配)做眼表检查,包括泪膜破裂时间(BUT),泪液分泌试验(Schirmer I),角膜荧光素染色,结膜印迹细胞学榆查,并对结果进行统计学分析.结果尿病组98.0%的眼泪膜破裂时间小于10s,泪膜破裂时间(4.56±2.02)s低于对照组(6.76±4.11)s;66.0%的患者泪液分泌试验小于5mm,泪液分泌值(4.52±2.84)mm低于对照组为(6.28±3.65)mm;角膜上皮着色占58.0%,结膜杯状细胞密度下降,鳞状上皮化生程度加重.结论糖尿病患者泪膜稳定性显著下降,是引起十眼症的主要原因.对糖尿病病人进行泪膜破裂时间、泪液分泌试验、角膜荧光素染色、结膜印记细胞学检查有助于早期发现糖尿病的角结膜上皮病变.
목적 통과대2형당뇨병환자적루막화안표병변진행림상검측,탐토2형당뇨병여루막화각결막상피개변적상관성.방법 대25례(50지안)당뇨병주원환자화25례(50지안)무당뇨병자(년령필배)주안표검사,포괄루막파렬시간(BUT),루액분비시험(Schirmer I),각막형광소염색,결막인적세포학유사,병대결과진행통계학분석.결과 뇨병조98.0%적안루막파렬시간소우10s,루막파렬시간(4.56±2.02)s저우대조조(6.76±4.11)s;66.0%적환자루액분비시험소우5mm,루액분비치(4.52±2.84)mm저우대조조위(6.28±3.65)mm;각막상피착색점58.0%,결막배상세포밀도하강,린상상피화생정도가중.결론 당뇨병환자루막은정성현저하강,시인기십안증적주요원인.대당뇨병병인진행루막파렬시간、루액분비시험、각막형광소염색、결막인기세포학검사유조우조기발현당뇨병적각결막상피병변.
Objective To investigate the diabetic tear film function and OCUlar surface diseases in order to discover the possible pathological mechanism of keratoconjunctival epithelium diseases.Methods Twenty-five patients with type 2 DM and 25 non-diabetic controls(age and sex matched)were included in this study.Corneal sensitivity measurement,Schirmegs I test,tear film break up time(BUT)measurement,fluorescein staining of the cornea,and conjuctival impression cytologic analysis(CIC)were examined.Results The corneal sensitivity,Schirmer's test values and BUT were significantly lower than the control group,conjunctival goblet cell density lower in the diabetic cases.The fluorescein staining increased in the diabetic group.Average score of FL and the grade of conjunctival squamous metaplasia were higher than healthy subjects,and the difference between two groups was statistical significance(P＜0.05).Conclusions The tear film dysfunction in non-insulin dependent diabetics makes these persons getting dry eye more commonly.The corneal sensitivity measurement,Schirmer's I test,tear film break up time(BUT)measurement and fluorescein staining of the cornca should become routine tests in diabetes mellitus patients,