沈阳化工大学学报
瀋暘化工大學學報
침양화공대학학보
JOURNAL OF SHENYANG INSTITUTE OF CHEMICAL TECHNOLOGY
2012年
1期
22-25
,共4页
来福胶囊%超氧化物歧化酶(SOD)%还原型谷胱甘肽(GSH)%丙二醛(MDA)
來福膠囊%超氧化物歧化酶(SOD)%還原型穀胱甘肽(GSH)%丙二醛(MDA)
래복효낭%초양화물기화매(SOD)%환원형곡광감태(GSH)%병이철(MDA)
life capsule%superoxide dismutase (SOD)%glutathione reduced (GSH)%malondialdehyde (MDA)
研究不同剂量来福胶囊对环磷酰胺所致的小鼠损伤的保护与修复作用.给小鼠连续灌服来福胶囊45 d后,用环磷酰胺建损伤模型,再连续灌服来福胶囊45 d,然后测定血常规、超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）和丙二醛（MDA）.结果显示低剂量组SOD和GSH值升高,MDA值最低,而高、中剂量组有时会出现相反情况.因此,连续口服低剂量来福胶囊有增强机体的抗氧化作用,对化疗药引起的损伤有一定修复作用.
研究不同劑量來福膠囊對環燐酰胺所緻的小鼠損傷的保護與脩複作用.給小鼠連續灌服來福膠囊45 d後,用環燐酰胺建損傷模型,再連續灌服來福膠囊45 d,然後測定血常規、超氧化物歧化酶（SOD）、還原型穀胱甘肽（GSH）和丙二醛（MDA）.結果顯示低劑量組SOD和GSH值升高,MDA值最低,而高、中劑量組有時會齣現相反情況.因此,連續口服低劑量來福膠囊有增彊機體的抗氧化作用,對化療藥引起的損傷有一定脩複作用.
연구불동제량래복효낭대배린선알소치적소서손상적보호여수복작용.급소서련속관복래복효낭45 d후,용배린선알건손상모형,재련속관복래복효낭45 d,연후측정혈상규、초양화물기화매（SOD）、환원형곡광감태（GSH）화병이철（MDA）.결과현시저제량조SOD화GSH치승고,MDA치최저,이고、중제량조유시회출현상반정황.인차,련속구복저제량래복효낭유증강궤체적항양화작용,대화료약인기적손상유일정수복작용.
To study protection and rehabilitation of Life Capsule on medication trauma in mice,trauma model in mice was made by Cyclophosphamide （i.p.） after administering （p.o.） Life Capsule for 45 days.Then Life Capsule was continuously administered for 45 days.Lastly Blood routine,Superoxide Dismutase （SOD）,Glutathione Reduced （GSH） and malondialdehyde （MDA） were determined.The results showed that the levels of SOD and GSH were increased and level of MDA was the lowest in low dosage group,but reverse results appeared sometimes in high and medium groups.Thus antioxidation in organism was improved by administering （p.o.） low dosage life capsule continuously for long time and Life Capsule can protect and rehabilitate medication trauma in a certain extent.
