CAJ | 학술논문

目的观察运动锻炼对高血压患者氧化应激及炎症因子的影响。方法选取73例高血压患者随机分为干预组和对照组。干预组继续药物治疗的基础上给予为期6个月的运动锻炼，对照组药物治疗同前，并保持平静生活方式。结果通过6个月的运动锻炼，干预组和对照组比较结果显示体重[（69±8）kg vs．（73±8）kg]、收缩压[（137.7±5.8）mm Hg vs．（141.7±6.9）mm Hg]、舒张压[（81.7±4.7）mm Hg vs．（84.9±5.9）mm Hg]下降，血清丙二醛[（6.65±1.4）μmol/L vs．（7.65±1.3）μmol/L]、高敏C反应蛋白[（6.68±1.76）mg/L vs．（7.89±1.23）mg/L]、白细胞介素-6[（10.54±3.27）pg/ml vs．（12.95±4.35）pg/ml]、肿瘤坏死因子-α[（5.48±1.76）pg/dl vs．（7.68±3.26）pg/dl]降低，超氧化物歧化酶[（92.87±14.8）U/ml vs．（84.56±15.9）U/ml]、一氧化氮[（82.56±11.7）μmol/L vs．（75.92±15.9）μmol/L]含量升高（均P＜0.05）。结论运动锻炼能降低高血压患者体重、血压，还能改善高血压患者氧化应激及炎症状态。
목적관찰운동단련대고혈압환자양화응격급염증인자적영향。방법선취73례고혈압환자수궤분위간예조화대조조。간예조계속약물치료적기출상급여위기6개월적운동단련，대조조약물치료동전，병보지평정생활방식。결과통과6개월적운동단련，간예조화대조조비교결과현시체중[（69±8）kg vs．（73±8）kg]、수축압[（137.7±5.8）mm Hg vs．（141.7±6.9）mm Hg]、서장압[（81.7±4.7）mm Hg vs．（84.9±5.9）mm Hg]하강，혈청병이철[（6.65±1.4）μmol/L vs．（7.65±1.3）μmol/L]、고민C반응단백[（6.68±1.76）mg/L vs．（7.89±1.23）mg/L]、백세포개소-6[（10.54±3.27）pg/ml vs．（12.95±4.35）pg/ml]、종류배사인자-α[（5.48±1.76）pg/dl vs．（7.68±3.26）pg/dl]강저，초양화물기화매[（92.87±14.8）U/ml vs．（84.56±15.9）U/ml]、일양화담[（82.56±11.7）μmol/L vs．（75.92±15.9）μmol/L]함량승고（균P＜0.05）。결론운동단련능강저고혈압환자체중、혈압，환능개선고혈압환자양화응격급염증상태。
Objective To observe the effects of physical exercises on oxidative stress and inflammatory factor levels in patients with hypertension .Methods A total of 73 patients with essential hypertension were randomly assigned to the intervention group ( n=36;doing physical exercise once a day ,5 days a week ) or control group ( n=37,keeping sedentary life).All the patients received standard treatment.At the beginning and at 6 months,body weight(BT),systemic blood pressure(SBP),diastolic blood pressure(DBP)and heart rate(HR)were recorded, serum malondialdehyde(MDA),superoxide disnmtase(SOD),nitric oxide(NO),hs-C reactive protein(hs-CRP), interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were measured.Results At 6 months,BT[(69 ±8)kg vs. (73 ±8)kg],SBP[(137.7 ±5.8)mm Hg vs.(141.7 ±6.9)mm Hg],DBP [(81.7 ±4.7)mm Hg vs.(84.9 ± 5.9)mm Hg],serum MDA[(6.65 ±1.4)μmol/L vs.(7.65 ±1.3)μmol/L],hs-CRP[(6.68 ±1.76)mg/L vs. (7.89 ±1.23)mg/L],IL-6[(10.54 ±3.27)pg/ml vs.(12.95 ±4.35)pg/ml]and TNF-α[(5.48 ±1.76)pg/dl vs.(7.68 ±3.26)pg/dl]were significantly decreased in the intervention group when compared with the control goup (all P<0.05),while serum SOD[(92.87 ±14.8)U/ml vs.(84.56 ±15.9)U/ml]and NO[(82.56 ±11.7)μmol/L vs.(75.92 ±15.9)μmol/L]were significantly increased(both P<0.05).Conclusion Physical exercises could play a role in reducing body weight , blood pressure , improving oxidative stress and decreasing inflammatory factor levels in patients with hypertension .