CAJ | 학술논문

目的：评价病灶周围组织与病灶表观扩散系数(apparent diffusion coefficient,ADC)的差值在乳腺良恶性病变诊断中的应用价值。方法64例患者经扩散加权成像(diffusion weighted imaging,DWI)及动态增强 T1 WI 共发现65个可疑病灶。测量病灶周围腺体的 ADC 值和病灶 ADC 值,计算出差值。利用 ROC 曲线评价 ADC 差值法在诊断乳腺病灶良恶性中的表现。结果65个病灶中有35个恶性,30个良性,病灶 ADC 值最佳诊断点为1.28×10-3 mm2/s,诊断的敏感性和特异性分别为76.7%和94.3%；ADC 差值法最佳诊断点为0.63×10-3 mm2/s,诊断的敏感性和特异性分别为88.6%和96.7%。结论 ADC 差值法能够减少个体生理因素、不同机型、扫描参数对 ADC 值的影响,在诊断乳腺病灶良恶性方面有较高的诊断价值。
목적：평개병조주위조직여병조표관확산계수(apparent diffusion coefficient,ADC)적차치재유선량악성병변진단중적응용개치。방법64례환자경확산가권성상(diffusion weighted imaging,DWI)급동태증강 T1 WI 공발현65개가의병조。측량병조주위선체적 ADC 치화병조 ADC 치,계산출차치。이용 ROC 곡선평개 ADC 차치법재진단유선병조량악성중적표현。결과65개병조중유35개악성,30개량성,병조 ADC 치최가진단점위1.28×10-3 mm2/s,진단적민감성화특이성분별위76.7%화94.3%；ADC 차치법최가진단점위0.63×10-3 mm2/s,진단적민감성화특이성분별위88.6%화96.7%。결론 ADC 차치법능구감소개체생리인소、불동궤형、소묘삼수대 ADC 치적영향,재진단유선병조량악성방면유교고적진단개치。
Objective To evaluate the difference of the surrounding normal tissue and lesion apparent diffusion coefficient (appar-ent diffusion coefficient,ADC)value in identify malignant and benign breast lesions.Methods There were 65 suspicious malignant breast lesions received by DWI scan and dynamic contrast-enhanced MRI (DEC-MRI)in 64 patients.The ADC value of breast lesions and peripherial glands were respectively measured,and then the difference was calculated.Receiver operating characteristic curve (ROC)analysis was used to evaluate the difference’s performance in identification between benign and malignant breast lesions.Re-sults There were 35 malignant lesions and 30 benign lesions.For the malignant lesions,the optimal threshold values for ADC of breast lesions were 1.28×10-3 mm2/s.The area under the ROC was 92.2%,the sensitivity and specificity were 76.7% and 94.3%.While the optimal threshold values for ADC were 0.63×10 -3 mm2/s in the benign lesions.The area under the ROC was 94.9%,the sensitivity and specificity were 88.6% and 96.7%.Conclusion ADC difference can reduce the influences of individual physiological factors,different machine,scanning parameters,which play an important role in identification between benign and malignant breast lesions.